Table 4.

Univariate and Multivariate Regression relationship of genetic polymorphism with ln (t-PA) and ln (PAI-1) including outliers

Gender	Dependent variable	Independent variables
		Polymorphisms	R2 × 100	P value	Change R2 × 100%a	Full model R2 × 100%	P value for F changea
Female	t-PAb	Renin (rs1464816)e	0.7	0.049	0.8	19.1	0.020
	PAI-1b	PAI 4G5G (rs1799768)c	0.8	0.029	1.7	19.4	0.001
Male	t-PAb	TPA I/D(rs4646972)c	1.2	0.026	1.6	17.3	0.004
		Renin (rs3730103)c	1.3	0.019	1.1	16.8	0.020
	PAI-1b	Renin (rs1464816)e	0.9	0.046	0.6	24.1	0.069
		Ethanolamine kinase 2 (Rs1917542)c	0.8	0.066	0.6	24.1	0.079
		Renin (Rs3730103)d	1.0	0.040	0.6	24.1	0.064
		TPA I/D (rs4646972)d	1.0	0.044	1.1	24.6	0.014

^aAdjusted for full model (Table 1)

^bNatural log transformed

^cAdditive encoding

^dRecessive encoding

^eDominant encoding