Fig. 2.

Kinetics of WBC decrement during CO treatment. Weekly WBC counts were performed on 7 age-matched S+S-Antilles mice for 2 consecutive wk to determine mean baseline WBC (week 0). The mice then received 250 ppm inhaled CO 1 h/day, 3 days/wk, 1 h/day, with a blood sample drawn weekly to assess total WBCs. After 7 wk of CO, there was a significant decrease in mean WBC counts. CO treatments were continued for an additional week (week 8) and then discontinued. The mean WBC counts of the mice remained significantly lower for 5 wk (weeks 9–13) after CO withdrawal. Values are means ± SE. #P < 0.05 compared with baseline using a one-way repeated-measure ANOVA.