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. 2009 Jul 24;297(4):H1387–H1397. doi: 10.1152/ajpheart.00638.2008

Fig. 3.

Fig. 3.

Increase in Kir2.3 current requires SAP97 binding motif on channel COOH terminal. A: current density-voltage relationship of transiently transfected Kir2.3 wild-type and mutant (Kir2.3 ΔSAI) channels in HEK cells (Kir2.3 wild type N = 6; Kir2.3 ΔSAI N = 7). B: SAP97-induced increase in current wild-type Kir2.3 channels (Kir2.3 wild type N = 6; Kir2.3 wild type + SAP97 N = 5). C: SAP97 does not increase whole cell currents in Kir2.3 ΔSAI channels (Kir2.3 ΔSAI N = 7; Kir2.3 ΔSAI + SAP97 N = 5). D: transfecting SAP97 does not induce Kir2.3-like currents in HEK cells [green fluorescent protein (GFP) N = 4; GFP + SAP97 N = 6]. E: SAP97 effects on peak inward and peak outward current density from data presented in B–D.