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csCnb1−/− mice [mice with cardiac-restricted deletion of the calcineurin (Cn) b1 gene; solid line, n = 19] exhibit increased mortality compared with control mice [dashed line; csCnb1+/+, n = 5; myosin heavy chain-Cre+ (Cre+) n = 5]. Graph represents percent survival through 9 mo of life. Early mortality begins at 2½ mo of age, and by 6 mo of age nearly all csCnb1−/− mice died.
