Fig. 4.
Ventricular contraction and relaxation are impaired in csCnb1−/− mice. Graphical representation of functional data (means ± SE) was obtained from control and csCnb1−/− mice during closed-chest cardiac catheterization, measured at baseline and with increasing dosage of infused dobutamine. A: heart rate (HR). B: rate of pressure development (+dP/dt). C: rate of pressure relaxation (−dP/dt). D: left ventricular end diastolic pressure (LVEDP). E: tau (time constant). F: maximal left ventricular pressure (LVPmax). Control mice (n = 4) are indicated by open circles; csCnb1−/− mice (n = 4) by solid circles. †P < 0.05, analysis of covariance comparing genotypes. *P < 0.05, for pairwise comparisons between genotypes at the same dobutamine dosage. BW, body weight; bpm, beats/min.