Fig. 2.

Responses of MCA to ACh (A), reduced PO₂ (B), and iloprost (C) in rats fed a HS diet (n = 8), HS diet with an intravenous infusion of dimethylsulfoxide (DMSO) vehicle alone (n = 5), HS diet with ANG II infusion (n = 5), HS diet with a simultaneous infusion of ANG II plus either the MEK inhibitor PD-98059 (PD; n = 7), the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin (Wort; n = 6), the P38 MAPK inhibitor SB-203580 (SB; n = 6), or the eukaryotic protein synthesis inhibitor cycloheximide (CHX; n = 6). Data are summarized as mean changes from control diameter (in μm) ± SE. *P < 0.05: HS, HS + DMSO, HS + ANG II + PD, and HS + ANG II + CHX vs. HS + ANG II; †P < 0.05: ACh response with HS + ANG II + Wort vs. HS + ANG II alone; #P < 0.05: ACh response with HS + ANG II + SB vs. HS + ANG II alone.