Fig. 4.

Responses of MCA to ACh (A), reduced PO₂ (B), and iloprost (C) in rats fed a LS diet alone (n = 9) or LS diet with an intravenous infusion of either the EGF receptor kinase inhibitor AG-1478 (AG; n = 6), the MEK inhibitor PD-98059 (PD; n = 7); the PI3K inhibitor wortmannin (Wort; n = 6), the P38 MAPK inhibitor SB-203580 (SB; n = 6), or the eukaryotic protein synthesis inhibitor cycloheximide (CHX; n = 6). Data are summarized as mean changes from control diameter (in μm) ± SE. *P < 0.05: LS + AG, LS + PD, and LS + CHX vs. LS alone; †P < 0.05: ACh response in LS + Wort vs. LS alone.