Table 2.
Parameters of the voltage dependence of activation and inactivation for currents separated by 50 μM NiCl2
| Voltage Dependence | 50 μM Ni2+ Sensitive |
50 μM Ni2+ Resistant |
||
|---|---|---|---|---|
| Activation | Inactivation | Activation | Inactivation | |
| Control “Early” | ||||
| V1/2 | −30.5±3.7 (8) | −66.6±2.8 (6) | −32.3±3.9 (8) | −68.8±3.7 (5) |
| k | 10.4±1.4 | −4±1 | 8.3±2.4 | −7.5±0.9 |
| AR | ||||
| V1/2 | −10.5±2.9‡ (8) | −61.6±1* (7) | −15.7±4.4† (7) | −67.7±2.2 (6) |
| k | 8.9±0.8 | −5.7±0.6 | 8.9±0.8 | −7.5±0.8 |
| T24R | ||||
| V1/2 | −20.9±3.4 (5) | −66.6±4 (4) | −22.5±6.8 (5) | −72.4±3 (4) |
| k | 10.9±1.1 | −7.5±2.5 | 14.4±2.1 | −7.4±0.4 |
| Control “Late” | ||||
| V1/2 | −17.5±5.1 (3) | −58.6±1.9 (5) | −31.8±6.6 (4) | −78.3±4.7 (5) |
| k | 8.8±1.1 | −5.5±1.7 | 9.2±2.9 | −8.6±2.1 |
| CR | ||||
| V1/2 | −25.1±4.7 (6) | −61.1±4.9 (7) | −22.2±4.6 (7) | −62.8±4.9 (6)* |
| k | 8.6±1.1 | −8.6±1.1 | 9.3±1.4 | −6.9±0.6 |
Values are means ± SE for (n) recordings. V1/2 and k values are derived from Boltzmann fit.
*
P < 0.05,
†
P < 0.01,
‡
P < 0.001. Statistical significance is calculated vs. “early” control myocytes.