Hemodynamic changes (%) of baseline value after isoproterenol stimulation in mice (n = 8–9 for each group). In WT and β2ARKO mice, heart rate, dP/dtmax, maximal power, and Ees are significantly increased compared with basal levels, with no significant increase seen in β1AR or DKO mice (A–D). *P < 0.005 WT or β2AR vs. β1AR or DKO, #P < 0.05 WT or β2AR vs. β1AR or DKO.