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βAR density and CaMKII activity following MI in βAR knockout mice (n = 5 for each group). A: only β1ARs are downregulated 8 wk post-MI, whereas receptor densities of β2ARs remain unchanged. *P < 0.05 sham vs. MI within group. B: CaMKII activity post-MI. C: sham hearts. The presence of β1AR stimulates Ca2+-dependent CaMKII activity after MI. *P < 0.05 Ca2+ dependent vs. Ca2+ independent within group.
