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Interaction of p27 with H1944 cell proliferation. A: PTHrP-positive H1944 cells contained 67% less p27 after treatment with anti-p27 lentiviral small interfering RNA (siRNA) particles compared with nonsilencing particles. The p27 knockdown resulted in a 60% increase in Rb phosphorylation and a 15% increase in thymidine incorporation over 24 h (B) compared with control cells treated with nonsilencing siRNA. *P < 0.05.
