Fig. 8.

PTHrP effects in MV522 lung adenocarcinoma cells. A: 24-h thymidine uptake was reduced by 25% in PTHrP-producing MV522 cells compared with vector controls. B: cyclin A2, cyclin D1, cyclin D2, and cyclin D3 levels were reduced in PTHrP-producing clones compared with controls. C: less cyclin A2 was associated with CDK2 in PTHrP-positive cells than in the PTHrP-null line. D: PTHrP-expressing cells demonstrated greater levels of ERK phosphorylation than did the controls. *P < 0.05. **P < 0.01.