Table 4.

Cotinine substitution concentrations

Period	Patch and nicotine spray				Patch and placebo spray
	Users*	Mean	% of baseline cotinine†		Users*	Mean	% of baseline cotinine†
Baseline	111	378	100		111	341	100
1 day	94	227	60.1		90	170	49.9
15 days	61	171	45.2		56	128	37.5
43 days	31	192	50.8		38	136	39.9
3 months	16	191	50.5		27	88	25.8
6 months	8	226	59.8		0	0	0
12 months	4	495	131		0	0	0

^*Those abstinent in respective treatment groups and using prescribed nicotine as either patch with nicotine nasal spray or patch only. At baseline, users refers to smokers. 

^†Percentages at each follow up derived from mean cotinine concentration at baseline.