Table 1.
Percentage or mean (SD); range | |
---|---|
Gender | 56% men |
Age (years) | 66.6 (9.9); 46–89 |
Education (years) | 16.9 (2.2); 12–21 |
Duration of PD diagnosis (years) | 6.9 (5.0); 1–23 |
Modified Hoehn and Yahr stage 1 | 25.0% |
Modified Hoehn and Yahr stage 1.5 | 0.0% |
Modified Hoehn and Yahr stage 2 | 40.6% |
Modified Hoehn and Yahr stage 2.5 | 28.1% |
Modified Hoehn and Yahr stage 3 | 6.3% |
History of clinical fluctuationsa,b | 46.4% |
History of dyskinesiasa,b | 28.6% |
History of fallsb,c | 19.4% |
Sleep disturbancesa | 50.0% |
L-dopa equivalents (mg/day)d | 546.2 (404.3); 0–2101 |
Medication type (%) | |
L-dopa | 91 |
Dopamine agonist | 69 |
MOA-B-inhibitor (Selegiline) | 31 |
COMT-inhibitor (Entacapone) | 22 |
Amantadine | 19 |
Anticholinergic (Trihexyphenidyl) | 9 |
CoQ10 | 9 |
Psychotropic/other | 6 |
Notes: SD = standard deviation; L-dopa medications include levodopa–carbidopa, levodopa–carbidopa–entacapone, carbidopa, levodopa; dopamine agonist medications include pramipexole, ropinirole, pergolide; Psychotropic/other medications included Paroxetine for depression and Neurontin for pain. Those on Stalevo were considered to be on both L-dopa and a COMT-inhibitor.
aFour to five participants' scores were unavailable for these questions.
bScores were dichotomized (feature present or not present).
cOne participant's score was unavailable.
dL-dopa equivalents = regular levodopa dose × 1 + levodopa continuous release (CR) dose × 0.75 + pramipexole dose × 67 + ropinirole dose × 16.67 + pergolide dose × 100 + bromocriptine dose × 10 + [regular levodopa dose + (continuous release levodopa dose × 0.75)] × 0.25 if taking tolcapone (Hobson et al., 2002); one participant's L-dopa equivalent could not be calculated because of missing dosages.