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. Author manuscript; available in PMC: 2009 Oct 30.
Published in final edited form as: Nature. 2009 Aug 13;460(7257):855–862. doi: 10.1038/nature08304

Figure 2. Designed metalloproteins using native scaffolds.

Figure 2

a, Native nickel binding site of NikR (left) and the re-engineered UO22+ binding site of the mutated NikR (right). b, Loop directed mutagenesis of blue copper azurin to yield the dinuclear, purple CuA azurin construct. c, Catalytic heme-copper center in CcO (left) and the designed heme-cooper model in sperm whale Mb (right).