Figure 2.

Cyclin D2 mRNA expression in mature B-cell NHL. Quantitatitve RT-PCR analysis of cyclin D2 was performed relative to the TBP housekeeping gene and results are depicted as ratio of cyclin D2/TBP transcript numbers. The horizontal line indicates the cut-off value for altered cyclin D2 expression (cycD2/TBP ratio=15.4), which corresponds to the mean value of cyclin D2 in normal lymph nodes (cycD2/TBP ratio=6.8) plus three standard deviations (SD:2.8). The difference in cyclin D2 expression between cyclin D2⁺ MCL and the remaining cases is statistically significant (p=0.04).