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. 2009 Sep 10;28(20):3074–3089. doi: 10.1038/emboj.2009.255

Figure 4.

Figure 4

Opa1 amount controls both fusion quantity and quality. (A) Effects of Opa1 siRNA, overexpression (OE) or AV on expression levels of Opa1. (B) Effects of Opa1 siRNA, OE, or AV on mitochondrial morphology. (C) Effects of Opa1 siRNA on mitochondrial fusion quantity and quality. Means±s.e.m.; P⩽0.03. (D) Effects of Opa1 OE or AV mitochondrial fusion quantity and quality. Means±s.e.m.; *P⩽0.003. (E) The time course of typical side-by-side complete fusion after photoactivation in Opa1-overexpressing cells. The donor (yellow) mitochondria moves into oblique opposition with the accepter. At 0 s the transfer of photoactived mtPAGFP has begun. Two mitochondria completely fuse to one at 56 s. (F) Summary of Opa1 amount effects on fusion quantity and quality.