Skip to main content
. Author manuscript; available in PMC: 2010 Oct 29.
Published in final edited form as: Neuron. 2009 Oct 29;64(2):200–212. doi: 10.1016/j.neuron.2009.09.021

Figure 2.

Figure 2

Temperature induces changes in spontaneous activity patterns of RGCs in WT and β2KO. (A) Peristimulus time histograms (PSTHs) of the mean spike rate of all neurons (bottom) at 30°C and 37°C (denoted by gray bar) from a P6 WT retina as well as single unit activity of 30 RGCs from a ten minute segment of the recording at 30°C (top left; denoted by open bar in bottom) and 37°C (top right; denoted by black bar in bottom). (B) PSTHs of the mean spike rate of all neurons (bottom) at 30°C and 37°C (denoted by gray bar) from a P6 β2KO retina as well as single unit activity of 30 RGCs from a ten min segment of the recording at 30°C (top left; denoted by open bar in bottom) and 37°C (top right; denoted by black bar in bottom). Correlated activity is seen at 37°C but not 30°C in the β2KO and the pattern of this activity is considerably different from WT patterns at either 30°C or 37°C. (C) High resolution spike rasters from WT (top) and β2KO (bottom) demonstrate that β2KO bursts appear to contain fewer spikes than WT. (D) RGCs spike more at 37°C (black) than at 30°C (gray) in both WT (left) and β2KO (right) retinas. (E) Waves occur more frequently at 37°C (black) than at 30°C (gray) in both WT (left) and β2KO (right) retinas. Data in (D) and (E) are from WT 37°C: 4378 neurons from 17 retinas; WT 30°C: 1331 neurons from 7 retinas, β2KO 37°C: 4078 neurons from 12 retinas, and β2KO 30°C: 2127 neurons from 6 retinas. Error bars represent SEM. ** p < 0.01; *** p < 0.001.