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. Author manuscript; available in PMC: 2010 Oct 29.
Published in final edited form as: Neuron. 2009 Oct 29;64(2):267–280. doi: 10.1016/j.neuron.2009.08.037

Figure 2. Separation of putative entorhinal principal cells and interneurons.

Figure 2

(A) Autocorrelograms and average filtered (0.8–5kHz) waveforms of a putative EC2 principal cell (light blue) and an EC3 interneuron (magenta). Right, Cross-correlogram revealed short-latency monosynaptic interactions between the neuron pair. Neuron 1 excites neuron 2 (these neurons were recorded from two different electrodes). Dashed lines indicate 1% and 99% global confidence intervals estimated by spike jittering on a uniform interval of [−5,5] msec (Fujisawa et al., 2008). (B) Same display as in A but for an EC3 interneuron-principal cell pair (also recorded from two different electrodes). Note short-latency suppression of spikes in the target neuron. (C) Putative principal cells and interneurons (empty symbols; orange, 1490 principal cells, violet, 327 interneurons) separated by waveform asymmetry and trough-to-peak latency (see inset; 0.8–5 kHz; Sirota et al., 2008) and other criteria (see Supplemental Methods). Filled orange and violet symbols correspond to excitatory (557 cells) and inhibitory (263 cells) neurons, respectively identified by monosynaptic interactions (as in A and B; see also Figure S3). Total of 2744 EC neurons. (D) Interspike intervals (mean ± SEM) of EC principal cells and interneurons. Bin size = 1msec.