Skip to main content
. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Neuropsychopharmacology. 2009 May 13;34(10):2197–2207. doi: 10.1038/npp.2009.47

Figure 5.

Figure 5

The anxiogenic effect of fluoxetine produced in juvenile animals is recapitulated on re-exposure to the drug in adulthood in the NIH test in SW, but not B6 mice. (A) Re-administration of 12 mg/kg/day dose for 4 weeks (12–16 weeks of age) in the SW mice resulted in increased approach latencies in the novel cage in F→F compared to C→C and C→F treatment groups (ANOVA with LSD posthoc test: *p<0.05; **p<0.01). No differences were observed in the FST test between the groups. (B) Re-exposure to 12 mg/kg/day fluoxetine produced no change in B6 mice in the NIH test. (C-D) No fluoxetine effect in EPM and OF in B6 mice either. CC: Controljuvenile→Controladult, CF: Controljuvenile→ Fluoxetineadult, FC: Fluoxetinejuvenile →Controladult, FF: Fluoxetinejuvenile→Fluoxetineadult.