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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Bioorg Med Chem. 2009 Sep 18;17(21):7457–7464. doi: 10.1016/j.bmc.2009.09.022

Table 1.

Previously reported LPA antagonists identified using structure-based approaches. NE no effect

Antagonists IC50 (nM)
LPA1 LPA2 LPA3 LPA4 LPA5
Compound 1 NE NE 24
Imax = 69.8%		 NE NE
Compound 2 220 22 NE NE NE
Compound 3 NE 355
Imax = 53.3%		 30
Imax = 81.7%		 NE NE
Compound 4 27354 9 1230 NE NE
Compound 5 NE NE 4504
Imax = 50%		 NE NE