Table 3.

Screening assay of Compound 5 and similarity search matches. Comparison of LPA₃ inhibition by analog compounds. Compounds were tested using 10 μM against 200 nM LPA. Refer to Figure 3 for scaffold structures.

Compound	Hit2lead ID	Scaffold	R1	R2	% inhibition at 10μM
5	5747876	I			10
6	6582859	I			agonist
7	7886891	I			18
8	5759401	I			38
9	5233136	I			43
10	5751335	I			42
11	5770242	II		NO2	NE
12	7724589	II		CH3	62
13	5160780	II		NO2	38
14	7334533	II		CH3	NE
15	5750136	III			Agonist
16	7901752	III			10
17	5128706	IV			NE
18	7890363	IV			Agonist
19	5233285	IV			18
20	5765834	V			82