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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Bioorg Med Chem. 2009 Sep 18;17(21):7457–7464. doi: 10.1016/j.bmc.2009.09.022

Table 4.

Dose response data for select compounds.

LPA1 LPA2 LPA3 LPA4 LPA5
Compound 5 NE NE IC50 =4504 nM
Imax=50 %		 NE NE
Compound 20 IC50=94 nM
Ki=48 nM		 NE IC50=752 nM
Ki=230 nM		 NE IC50=463 nM
Ki=292 nM
Compound 12 IC50=609 nM
Ki=311 nM		 NE IC50=2992 nM
Ki=1084 nM		 NE NE
Compound 11 NE NE NE NE NE