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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Curr Opin Struct Biol. 2009 Oct 2;19(5):534–542. doi: 10.1016/j.sbi.2009.09.002

Figure 2.

Figure 2

Schematic representation of the CD-MPR (left) and CI-MPR (right). The MPRs are transmembrane glycoproteins. Various post-translational modifications are indicated, including palmitoylation and phosphorylation. The CD-MPR is shown as a dimer with each subunit having one Man-6-P binding site. The 15 repeating domains of the CI-MPR are numbered sequentially from the N-terminus to C-terminus. Domains 3, 5, and 9 bind Man-6-P with domain 5 preferentially binding to phosphodiesters. Domain 1 is known to bind to urokinase plasminogen activator receptor (uPAR) and plasminogen (Plg). Domain 11 binds IGF-II and Domain 13 has a fibronectin II insert.