Fig. 3.

Positive TCN identified by means of ICA in healthy controls (green) and pre-HD subjects (blue) during the delay period of a verbal working memory task (Wolf and Walter, 2005; Wolf et al., 2008a). Top right: Within a predominantly frontostriatal TCN, areas with decreased connectivity in pre-HD individuals versus healthy comparison subjects comprised the left ventro- and dorsolateral prefrontal cortex, the left parietal lobule, the left insula, the bilateral putamen and the right caudate. Bottom right: Within a predominantly frontoparietal TCN, areas with decreased connectivity in pre-HD individuals versus healthy comparison subjects comprised the left dorsolateral prefrontal cortex and the left superior parietal cortex (Wolf et al., 2008b). The 2nd level spatial maps are rendered on the anatomical templates implemented in MRIcron [http://www.sph.sc.edu/comd/rorden/mricron/] (left) and SPM5 (right).