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. 2009 Nov 11;4(11):e7593. doi: 10.1371/journal.pone.0007593

Table 3. Anti-nematodal effects of various compounds with known modes of action.

Test compounds Class High-Throughput Screening* (mM)
LD25 LD50 LD95
HWY-4213 Fungicide 0.171 (±0.089) 0.447 (±0.079) 0.944 (±0.002)
HWY-5038 Fungicide 0.366 (±0.092) 0.748 (±0.085) 1.442 (±0.093)
HCI 15014 Fungicide 1.144 (±0.115) >2 >2
HCI 15176 Fungicide 1.337 (±0.098) >2 >2
Morantel tartrate Muscle activity blocker 15.602 (±1.718) >50 >50

*Values are mean±SD (n = 3).

Each drug was tested over a 0–2 mM concentration range, except controls, which were tested at 0–4 mM (emamectin benzoate, abamectin and levamisol hydrochloride) or 0–50 mM (morantel tartrate,).

Since other control chemicals (e.g., emamectin benzoate, abamectin, levamisol hydrochloride) showed extremely low solubility which prevents preparation of the stock solution in DMSO, we were not able to get their LD50 values even at greater than 4 mM of each agent used under this assay condition.