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. 2009 May;18(5):909–920. doi: 10.1002/pro.100

Table III.

Paired t-Tests for the Significance of Additional Mutations to Double-Mutant Cycle Interaction Free Energies

		P (one tail)	P (two tail)
Paired t-test pH 5.8
ΔΔG_int (30, 180)^WT	ΔΔG_int (30, 180)^H27A	0.016	0.031
ΔΔG_int (30, 180)^WT	ΔΔG_int (30, 180)^H173A	0.149	0.297
ΔΔG_int (27, 30)^WT	ΔΔG_int (27, 30)^H180A	0.033	0.065
ΔΔG_int (27, 180)^WT	ΔΔG_int (27, 180)^H30A	0.060	0.120
Paired t-test pH 7.8
ΔΔG_int (30, 180)^WT	ΔΔG_int (30, 180)^H27A	<0.001	<0.001
ΔΔG_int (30, 180)^WT	ΔΔG_int (30, 180)^H173A	0.124	0.248
ΔΔG_int (27, 30)^WT	ΔΔG_int (27, 30)^H180A	<0.001	<0.001
ΔΔG_int (27, 180)^WT	ΔΔG_int (27, 180)^H30A	0.008	0.092