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. 2009 Nov 12;4(11):e7787. doi: 10.1371/journal.pone.0007787

Figure 4. Dysregulated PMA-induced IL-6 production in CD macrophages.

Figure 4

A Cytokine secretion from HC (n = 7) and CD (n = 10) macrophages following stimulation with 1 µg/ml PMA for six hours was assessed. IL-6 production was significantly elevated in macrophages from CD patients compared to HC subjects. B Measuring the effect of elevated IL-6 (1 ng/ml) on DNA fragmentation in the presence or absence of PMA stimulation. DNA fragmentation was unaltered by the inclusion of IL-6 in both HC (n = 7) and CD (n = 7) macrophages. Statistical analysis: Paired or unpaired t-test. Symbols: p<0.05 (*), p<0.01 (**), p<0.001 (***).