Table 2.

Lymph node and splenic histopathology seen in FIV-positive lions from the Okavongo Delta (N = 9).

Code name	Date	Lymph node histopathology									Spleen histopathology
		Lymph node location	Hypertrophy/Hyperplasia and reactivity				Involution and/or depletion				Hypertrophy	Involution and/or depletion			Degeneration
			Cortical follicular hypertrophy	Paracortical hypertrophy	Medullary plasmacytosis	Sinus histiocytosis (macrophages)	Cortical follicular atrophy	Paracortical atrophy	Cysts/dilated sinuses	Follicular hyalinosis	Follicular hypertropy	Follicular atrophy	Lymphocyte depletion	Follicular hyalinosis
PLE-0700	2004	Ca	–	–	+	+	–	++	–	–	–	+	+	–	Ap, Nc, PMN deg
PLE-1024	2003										– P	+	+++	+
PLE-1025	2002	Ab	–	++	–	–	++	–	–	–	+	+	+	–	Ap, Lcy, PMN deg
	2003										+	+	++	+
	2004	Ca	–	–	+	++	nta	nta	–	–	–	+	++	++
PLE-1026	2001	Ax-Asp	–	–	–	+	++	+	–	–
PLE-1726	2001	Ax-Asp	–	–	–	+	+++	+++	–	–
PLE-1738	2002	Ma	–	–	–	–	++	+++	–	+	+	–	–	–	Ap, PMN deg
	2002	Ab	+	+	–	+	++	–	–	+
PLE-1744	2004										–	+	+	+	Ap, PMN deg
PLE-1750	2003										– P	+	+	+
	2004										–	+	++	+
PLE-1756	2006	Pop	++	–	+	+	–	+	–	+	+	++	++	++
	2006	Ax	++	–	+	–	–	++	+	+
	2006	Oth	–	–	–	–	+++	+++	+++	+

Scoring code (for tissue categories as in Ida 2002)

– not present

+ mild

++ moderate

+++ severe

nta no tissue available

P follicules are present

Lymph node location

Ca caudal abdomenal (mammary)

Asp asperate peripheral LN

Ab abdomenal (cecal) LN

Ma mandibular LN

Pop popliteal LN

Ax axillary LN

Oth other not specified

Splenic degeneration

Ap apoptosis

Nc necrosis

PMN deg PMN degeneration assoc with trabeculae

Lcy lymphocytolysis

Biopsies from FIV-negative aged match control lions were not available for histology.