Figure 2.

Early prevention of invasive candidiasis in 23–29 week gestation infants. Predicted median and population variability range (10^th–90^th percentile) of fluconazole plasma concentrations from 100 simulated trials of preterm 23–29 week gestation infants treated with 3 mg/kg (A) or 6 mg/kg (B) twice weekly for 42 days starting in the first 5 days of life. Closed circles in (A) represent the observed fluconazole plasma concentrations in infants participating in a previous PK trial who received 3 mg/kgl. Dash line in B represents the median fluconazole concentration predicted in infants with serum creatinine of 1.2 mg/dl for first two weeks of therapy. (C) shows the predicted median fluconazole plasma concentrations in 23–29 week infants with renal insufficiency treated with 6 mg/kg weekly for first two weeks and then twice weekly beginning on day 14 when creatinine decreases to ≤1.0 mg/dl in simulation.