Figure 4.

AdK3 inhibits C6 tumor growth and angiogenesis. Tumors from AdCO1-treated (A) and AdK3-treated groups (B) are shown 10 days p.i. The extent of vascularization at the periphery of a representative tumor injected with AdCO1 (C) or AdK3 (D) is shown at day 5 p.i. Paraffin-embeded C6 sections from an AdCO1-injected (E) or AdK3-injected tumor (F) were submitted to vWF-immunostaining at day 10 p.i. The proportion of apoptotic cells was detected by the TUNEL method within sections from an AdCO1-injected (G) or AdK3-injected tumor (H). The same magnification was used for AdCO1- and AdK3-injected tumors.