. Author manuscript; available in PMC: 2009 Nov 2.

Published in final edited form as: Mach Learn. 2008 Oct;73(1):55–85. doi: 10.1007/s10994-008-5076-4

Table 1.

The predicates defined in the abduction ILP for learning metabolic network inhibition (Tamaddoni-Nezhad et al., 2006).

Predicate	Type	Description
`concentration(Metabolite,` `Level, Time)`	observable	at some Time a Metabolite has a certain Level of concentra- tion (up or down)
`reactionnode(Metabolites1,` `Enzymes, Metabolites2)`	background	a metabolic pathway between Metabolites1 and Metabo- lites2 catalyzed by Enzymes
`enzyme(Enzyme)`	background	a (sequence of) Enzyme(s)
`enzyme(Metabolite)`	background	a (set of) Metabolite(s)
`inhibited(Enzyme,` `true, Metabolites1,` `Metabolites2, Time)`	abducible	at Time the reaction from Metabolites1 to Metabolites2 is inhibited by the toxin through an adverse effect on Enzyme that catalyzes the re- action
`inhibited(Enzyme,` `false, Metabolites1,` `Metabolites2, Time)`	abducible	at Time the reaction from Metabolites1 to Metabolites2 is not inhibited by the toxin through an adverse effect on Enzyme that catalyzes the re- action