Table 6.

Interaction index and key dihedral angle which are correlated to the wild type activity.

Compd.	pIC50	Dist1a	Dist2a	Dihedralb	Indexc
17	8.82	4.533	4.825	−99.4	4.68
18	7.61	4.564	5.136	−108.1	4.85
23	8.96	4.471	4.988	−94.3	4.73
29	7.70	4.552	5.098	−98.2	4.83
30	8.34	4.545	4.833	−97.2	4.69
31	6.48	4.958	5.245	−114.3	5.10
32	8.43	4.654	4.876	−96.4	4.77
33	8.96	4.519	5.002	−93.7	4.76
38	8.74	4.449	4.974	−96.0	4.71
39	6.57	5.004	5.326	−116.6	5.17

^aIn Å;

^bC2-N1-C1′-C2′, in °;

^cIndex = (Dist1+Dist2)/2