Conceptual construct in which a biomarker (e.g., IGF-I) can be used to provide prognostic information with regard to the physiological status of soldiers. Optimal resolution of such a predictive model will likely be multifactorial and will include demographic, psychological, physical, and biochemistry information. Minimally invasive technologies that are field expedient, cost-effective, and allow for continuous and real-time feedback will have the greatest likelihood of being adapted and used in military environments.