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. Author manuscript; available in PMC: 2009 Nov 2.
Published in final edited form as: Nat Genet. 2008 Jun 15;40(7):871–879. doi: 10.1038/ng.104

Figure 6. Dishevelled links basal body docking to vesicle traffic and Sec8 localization.

Figure 6

A. TEM of control embryo. Basal bodies are docked and apical cytoplasm contains very few vesicles (arrowheads). B. TEM of Dvl morphant; basal bodies have failed to dock apically, and the apical cytoplasm contains numerous vesicles (arrowheads). C. Immunostaining reveals an orderly distribution of Sec8 in the apical surface of control multi-ciliated cells. c'. The Sec8 signal (green) associates evenly with basal bodies as indicated by Centrin immunostaining (red). D. Sec8 immunostaining is disordered in Dvl morphants. d'. The Sec8 signal (green) fails to associate with basal bodies (red) in Dvl morphants.