Table 1. Effect of DEET preparations on worm establishmenta.
Agent (in 100 μl) |
Schistosoma mansoni (in mice)b |
Schistosoma japonicum (in mice)c |
Schistosoma haematobium (in hamsters)d |
|||
---|---|---|---|---|---|---|
Sample size# | Percentage establishment | Sample size# | Percentage establishment | Sample size# | Percentage establishment | |
Isopropanol control | 10 | 78.47 ± 7.48 | 10 | 70.30 ± 11.06 | 5 | 46.00 ± 16.83 |
20% DEET | 10 | 0 ± 0 | 10 | 0 ± 0 | 10 | 0 ± 0 |
Liposome control | 10 | 82.60 ± 4.67 | ND | ND | 5 | 38.00 ± 17.27 |
20% LipoDEET | 10 | 0 ± 0 | 10 | 0 ± 0 | 10 | 0 ± 0 |
Ref. | [21] | –e | –f |
Worm establishment was determined by perfusion on Day 39–42 for Schistosoma mansoni, on Day 28–32 for Schistosoma japonicum and on Day 80–95 for Schistosoma haematobium. ND, no data available.
Mice were infected with 100 cercariae via the abdominal skin.
Mice were infected with 100 cercariae via the abdominal skin.
Hamsters were infected with 40 cercariae via the abdominal skin.
Data obtained from B. Salafsky et al. (2000) Topical application of a long-acting, safe, formulation of N-N-diethyl-m-toluamide (DEET) confers protection against Schistosoma japonicum. Abstract no. 507. 49th Annual meeting of the American Society of Tropical Medicine and Hygiene held 29th October to 2nd November 2000, in Houston, TX, USA.
Ramaswamy, K. and He, Y-X., unpublished data.