Table 2.
Adult (P63) basal levels (mean ± SE pg/μg tissue) of monoamines (norepinephrine [NE], dopamine [DA], serotonin [5-HT]) and metabolites (DOPAC and 5-HIAA) in limbic monoaminergic cell bodies following social defeat in adolescence.
| NE | DOPAC | DA | 5-HIAA | 5-HT | |
|---|---|---|---|---|---|
| Substantia nigra pars compacta (SNc) | |||||
| Social defeat | 23.83±2.25 | 11.86±0.79* | 48.08±3.69 | 30.98±2.52 | 53.04±5.51 |
| Control | 21.26±1.66 | 8.26±0.96 | 45.84±4.78 | 26.11±1.32 | 51.57±4.89 |
| Ventral tegmental area (VTA) | |||||
| Social defeat | 39.14±4.65 | 15.29±2.66 | 47.4±8.33 | 26.64±3.36 | 37.43±2.64 |
| Control | 37.82±2.09 | 11.59±1.21 | 42.56±7.13 | 27.18±1.31 | 38.27±3.62 |
| Dorsal raphe nucleus (dRN) | |||||
| Social defeat | 38.33±3.34* | 3.36±0.56 | 23.88±1.84 | 45.82±3.49 | 40.57±5.23 |
| Control | 57.14±7.52 | 3.32±0.56 | 29.61±3.57 | 52.54±5.48 | 55.21±7.03 |
| Median raphe nucleus (mRN) | |||||
| Social defeat | 26.27±2.37 | 2.71±0.51 | 17.16±5.26 | 50.42±4.4 | 38.96±5.0 |
| Control | 26.14±1.41 | 3.22±0.39 | 24.34±3.74 | 50.41±2.1 | 39.01±3.06 |
*
Significant difference between previously defeated rats and controls (p < 0.05).