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Activities of compounds showing general structure V against T. cruzi amastigotes (EC50) and Murine fibroblast cells (nM) (Scheme-7).
 | |||
|---|---|---|---|
| Compound | R | EC50T. cruzi (nM) | EC50 Fibroblasts (nM) |
| 44a | Cl | 1.2, 1.5, 2.1 | >1000 |
| 44b | CN | 1.5, 2.6 | >1000 |
| 44c | OCH3 | 0.8, 2.1 | >1000 |
| 44d | 2-benzothiazole | 0.4, 0.6, 0.7, 1.1, 1.4 | >1000 |
| 44e | 5-thiazole | 10, 13 | >1000 |
| 44f | C(=O)NHCH3 | 12, 26 | >1000 |
