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Model 3: (a) The subunit structure of the channel model. A conformational transition to an active state (state-A) occurs before the subunit can contribute to channel opening. (b) The open probability PO, (c) the mean open time τO, and (d) the mean close time τC. In the model K1=0.0054 μM, K2=17.6 μM, K3=0.64 μM, K4=K1K2∕K3, and K5=1.04 μM. For the conformational change, K0=0.135 μM and a0=535 μM−1 s−1.
