Table 2. Tag-SNPs associated with risk of glioma at p-trend<0.01 in pooled hospital-based case-control study of adult glioma conducted by the National Cancer Institute (NCI) and population-based case-control study of adult glioma conducted by the National Institute for Occupational Safety and Health (NIOSH).
| NCI | NIOSH | Pooled | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Region Gene |
SNP ID | Genotype | Control N (%) |
Case N (%) |
OR1,2 | 95% CI3 | Control N (%) |
Case N (%) |
OR4 | 95% CI | OR5 | 95% CI | ||
| SELP | ||||||||||||||
| SELP | rs39177276 | AA | 132 (40.1) | 129 (49.2) | 1.00 | 213(39.8) | 137(48.1) | 1.00 | 1.00 | |||||
| AG | 155 (47.1) | 102 (38.9) | 0.67 | 0.47-0.96 | 246(46.0) | 122(42.8) | 0.72 | 0.52-1.00 | 0.70 | 0.55-0.89 | ||||
| GG | 42 (12.8) | 31 (11.8) | 0.79 | 0.46-1.35 | 76 (14.2) | 26 (9.1) | 0.51 | 0.30-0.87 | 0.63 | 0.43-0.91 | ||||
| P trend | 0.103 | 0.005 | 0.001 | |||||||||||
| rs22368686 | GG | 86 (26.2) | 91 (34.6) | 1.00 | 140(26.3) | 94 (32.8) | 1.00 | 1.00 | ||||||
| AG | 159(48.5) | 113(43.0) | 0.66 | 0.44-0.97 | 259(48.7) | 131(45.6) | 0.75 | 0.53-1.08 | 0.71 | 0.54-0.92 | ||||
| AA | 83 (25.3) | 59 (22.4) | 0.67 | 0.43-1.06 | 133(25.0) | 62 (21.6) | 0.67 | 0.44-1.03 | 0.67 | 0.49-0.91 | ||||
| P trend | 0.068 | 0.059 | 0.007 | |||||||||||
| STAT1/STAT4 | ||||||||||||||
| STAT1 | rs2066804 | GG | 166 (50.3) | 164 (62.4) | 1.00 | 296(55.4) | 172(60.1) | 1.00 | 1.00 | |||||
| AG | 142 (43.0) | 85 (32.3) | 0.57 | 0.40-0.81 | 210(39.3) | 103(36.0) | 0.85 | 0.61-1.17 | 0.71 | 0.56-0.90 | ||||
| AA | 22 (6.7) | 14 (5.3) | 0.62 | 0.30-1.27 | 28 (5.2) | 11 (3.9) | 0.57 | 0.27-1.23 | 0.61 | 0.36-1.02 | ||||
| P trend | 0.004 | 0.113 | 0.002 | |||||||||||
| ITGB2 | ||||||||||||||
| ITGB2 | rs235325 | GG | 80 (24.2) | 91 (34.7) | 1.00 | 177(33.3) | 110(38.2) | 1.00 | 1.00 | |||||
| AG | 180 (54.6) | 127 (48.5) | 0.61 | 0.42-0.89 | 262(49.3) | 137(47.6) | 0.84 | 0.60-1.17 | 0.73 | 0.56-0.94 | ||||
| AA | 70 (21.2) | 44 (16.8) | 0.54 | 0.33-0.88 | 93 (17.5) | 41 (14.2) | 0.67 | 0.42-1.07 | 0.61 | 0.43-0.85 | ||||
| P trend | 0.007 | 0.086 | 0.002 | |||||||||||
| ALOX5 | ||||||||||||||
| ALOX5 | rs2291427 | GG | 170 (51.7) | 110 (41.8) | 1.00 | 240(44.9) | 125(43.4) | 1.00 | 1.00 | |||||
| AG | 137 (41.6) | 128 (48.7) | 1.47 | 1.04-2.09 | 244(45.7) | 120(41.7) | 1.01 | 0.72-1.40 | 1.21 | 0.95-1.53 | ||||
| AA | 22 (6.7) | 25 (9.5) | 1.76 | 0.93-3.33 | 50 (9.4) | 43 (14.9) | 1.85 | 1.12-3.04 | 1.85 | 1.25-2.74 | ||||
| P trend | 0.014 | 0.065 | 0.003 | |||||||||||
| NFKB1 | ||||||||||||||
| NFKB1 | rs4647992 | CC | 315 (95.7) | 234 (89.0) | 1.00 | 485(90.7) | 257(89.2) | 1.00 | 1.00 | |||||
| CT | 14 (4.3) | 28 (10.7) | 2.85 | 1.45-5.64 | 48 (9.0) | 31 (10.8) | 1.43 | 0.86-2.39 | 1.84 | 1.23-2.73 | ||||
| TT | 0 (0.0) | 1 (0.4) | ∞ | 2 (0.4) | 0 (0.0) | 0.00 | 1.01 | 0.08-12.36 | ||||||
| P trend | 0.001 | 0.340 | 0.005 | |||||||||||
| IRAK3 | ||||||||||||||
| IRAK3 | rs2701652 | GG | 167 (50.8) | 152 (57.8) | 1.00 | 243(45.8) | 149(51.9) | 1.00 | 1.00 | |||||
| CG | 128 (38.9) | 85 (32.3) | 0.71 | 0.50-1.02 | 230(43.3) | 122(42.5) | 0.86 | 0.62-1.19 | 0.80 | 0.63-1.02 | ||||
| CC | 34 (10.3) | 26 (9.9) | 0.87 | 0.49-1.53 | 58 (10.9) | 16 (5.6) | 0.40 | 0.22-0.76 | 0.60 | 0.40-0.91 | ||||
| P trend | 0.191 | 0.011 | 0.006 | |||||||||||
| SOD1 | ||||||||||||||
| SOD1 | rs202445 | TT | 210 (64.0) | 173 (65.8) | 1.00 | 334(63.6) | 207(72.4) | 1.00 | 1.00 | |||||
| CT | 103 (31.4) | 84 (31.9) | 0.95 | 0.66-1.35 | 169(32.2) | 74 (25.9) | 0.74 | 0.52-1.05 | 0.83 | 0.65-1.07 | ||||
| CC | 15 (4.6) | 6 (2.3) | 0.46 | 0.17-1.25 | 22 (4.2) | 5 (1.8) | 0.30 | 0.11-0.84 | 0.37 | 0.18-0.74 | ||||
| P trend | 0.271 | 0.007 | 0.006 | |||||||||||
| NCF2 | ||||||||||||||
| NCF2 | rs11579965 | CC | 293(88.8) | 221(84.0) | 1.00 | 471(88.2) | 239(83.0) | 1.00 | 1.00 | |||||
| CG | 35 (10.6) | 38 (14.5) | 1.48 | 0.90-2.45 | 62 (11.6) | 48 (16.7) | 1.47 | 0.95-2.27 | 1.47 | 1.06-2.04 | ||||
| GG | 2 (0.6) | 4 (1.5) | 2.61 | 0.46-14.72 | 1 (0.2) | 1 (0.4) | 4.24 | 0.26-69.36 | 2.99 | 0.67-13.40 | ||||
| P trend | 0.068 | 0.059 | 0.007 | |||||||||||
1
Odds ratio (OR).
2
ORs adjusted for sex, age, study hospital, and distance of residence from hospital.
3
95% confidence intervals.
4
ORs adjusted for sex, age, and state of residence.
5
ORs adjusted for study, sex, residence, and age within each study.
6
D' = 0.99 and r2 = 0.59 for pooled controls of European background.