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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1651–1658. doi: 10.1158/1055-9965.EPI-08-1041

Table 3. Tag-SNPs associated with risk of glioblastoma at p-trend<0.01 in pooled hospital-based case-control study of adult glioma conducted by the National Cancer Institute (NCI) and population-based case-control study of adult glioma conducted by the National Institute for Occupational Safety and Health (NIOSH).

NCI NIOSH Pooled
Region
Gene		 SNP ID Genotype Control
N (%)		 Case
N (%)		 OR1,2 95% CI3 Control
N (%)		 Case
N (%)		 OR4 95% CI OR5 95% CI
STAT1/STAT4
 STAT1 rs20668046 GG 166 (50.3) 83 (66.4) 1.00 296 (55.4) 78 (61.4) 1.00 1.00
AG 142 (43.0) 40 (32.0) 0.48 0.30-0.78 210 (39.3) 45 (35.4) 0.77 0.51-1.16 0.63 0.46-0.86
AA 22 (6.7) 2 (1.6) 0.14 0.03-0.66 28 (5.2) 4 (3.2) 0.50 0.17-1.50 0.30 0.12-0.72
P trend 0.00008 0.102 0.0001
 GLS rs130355046 CC 245 (74.5) 79 (63.2) 1.00 395 (74.4) 84 (65.1) 1.00 1.00
CG 81 (24.6) 43 (34.4) 1.63 1.00-2.66 123 (23.2) 39 (30.2) 1.50 0.96-2.34 1.55 1.12-2.15
GG 3 (0.9) 3 (2.4) 1.58 0.30-8.52 13 (2.5) 6 (4.7) 2.28 0.82-6.34 2.05 0.85-4.97
P trend 0.055 0.030 0.004
DEFB127/126
 DEFB127 rs14347897 TT 143 (43.3) 46 (36.8) 1.00 215 (40.3) 37 (28.9) 1.00 1.00
GT 147 (44.6) 62 (49.6) 1.26 0.78-2.04 270 (50.6) 64 (50.0) 1.40 0.89-2.19 1.34 0.97-1.86
GG 40 (12.1) 17 (13.6) 1.44 0.71-2.94 49 (9.2) 27 (21.1) 3.91 1.81-5.98 2.39 0.08-1.78
P trend 0.24 0.0002 0.0004
 DEFB126 rs60547067 TT 105 (31.9) 32 (25.6) 1.00 174 (32.7) 31 (24.2) 1.00 1.00
CT 165 (50.2) 68 (54.4) 1.45 0.86-2.45 269 (50.6) 65 (50.8) 1.41 0.88-2.27 1.43 1.00-2.04
CC 59 (17.9) 25 (20.0) 1.49 0.77-2.88 89 (16.7) 32 (25.0) 2.01 1.14-3.55 1.79 1.16-2.76
P trend 0.191 0.013 0.006
rs130368027 TT 131 (39.8) 41 (32.8) 1.00 222 (41.8) 43 (33.3) 1.00 1.00
CT 161 (48.9) 66 (52.8) 1.40 0.85-2.28 247 (46.5) 65 (50.4) 1.40 0.91-2.16 1.41 1.02-1.95
CC 37 (11.3) 18 (14.4) 1.66 0.81-3.40 62 (11.7) 21 (16.3) 1.79 0.96-3.24 1.74 1.09-2.77
P trend 0.112 0.040 0.009
SERPINI1
 SERPINI1 rs105136348 TT 232 (70.5) 104 (83.2) 1.00 408 (76.7) 108 (84.4) 1.00 1.00
AT 87 (26.4) 20 (16.0) 0.45 0.26-0.80 120 (22.6) 19 (14.8) 0.61 0.36-1.05 0.53 0.36-0.79
AA 10 (3.0) 1 (0.8) 0.22 0.03-1.92 4 (0.8) 1 (0.8) 0.84 0.09-7.54 0.38 0.08-1.78
P trend 0.002 0.079 0.001
rs15527468 TT 204 (61.8) 91 (72.8) 1.00 365 (68.6) 98 (76.6) 1.00 1.00
CT 109 (33.0) 33 (26.4) 0.71 0.43-1.16 152 (28.6) 28 (21.9) 0.68 0.43-1.09 0.69 0.49-0.98
CC 17 (5.2) 1 (0.8) 0.12 0.02-0.95 15 (2.8) 2 (1.6) 0.56 0.12-2.46 0.26 0.08-0.90
P trend 0.014 0.079 0.003
LY96
 LY96 rs16938755 TT 261 (79.1) 87 (69.6) 1.00 404 (75.8) 91 (70.5) 1.00 1.00
CT 63 (19.1) 33 (26.4) 1.51 0.89-2.56 123 (23.1) 34 (26.4) 1.35 0.86-2.12 1.42 1.00-2.00
CC 6 (1.8) 5 (4.0) 4.98 1.32-18.79 6 (1.1) 4 (3.1) 3.03 0.81-11.34 3.77 1.48-9.59
P trend 0.014 0.069 0.003
SELP
 SELP rs22368689 GG 86 (26.2) 42 (33.6) 1.00 140 (26.3) 47 (36.7) 1.00 1.00
AG 159 (48.5) 60 (48.0) 0.77 0.46-1.29 259 (48.7) 54 (42.2) 0.63 0.40-0.99 0.69 0.49-0.97
AA 83 (25.3) 23 (18.4) 0.49 0.26-0.92 133 (25.0) 27 (21.1) 0.59 0.34-1.01 0.54 0.36-0.82
P trend 0.027 0.040 0.003
rs39177279 AA 132 (40.1) 65 (52.0) 1.00 213 (39.8) 65 (51.2) 1.00 1.00
AG 155 (47.1) 48 (38.4) 0.68 0.42-1.08 246 (46.0) 49 (38.6) 0.63 0.41-0.96 0.65 0.48-0.89
GG 42 (12.8) 12 (9.6) 0.62 0.29-1.32 76 (14.2) 13 (10.2) 0.58 0.30-1.12 0.60 0.36-0.98
P trend 0.084 0.028 0.005
rs175237839 GG 167 (50.8) 74 (59.2) 1.00 259 (48.5) 76 (58.9) 1.00 1.00
GT 136 (41.3) 45 (36.0) 0.81 0.51-1.29 223 (41.8) 47 (36.4) 0.69 0.45-1.04 0.74 0.54-1.01
TT 26 (7.9) 6 (4.8) 0.53 0.20-1.41 52 (9.7) 6 (4.7) 0.43 0.18-1.05 0.47 0.24-0.91
P trend 0.152 0.028 0.005
C2
 C2 rs7746553 CC 232 (70.3) 82 (65.6) 1.00 377 (70.6) 75 (58.6) 1.00 1.00
CG 87 (26.4) 37 (29.6) 1.19 0.72-1.95 144 (27.0) 48 (37.5) 1.74 1.14-2.64 1.48 1.08-2.04
GG 11 (3.3) 6 (4.8) 1.72 0.56-5.29 13 (2.4) 5 (3.9) 2.15 0.72-6.43 1.99 0.90-4.37
P trend 0.292 0.006 0.006
CCL2/CCL7/CCL11/CCL8/CCL13/CCL1
 CCL2 rs2857653 CC 205 (63.1) 71 (56.8) 1.00 357 (67.1) 77 (59.7) 1.00 1.00
CT 105 (32.3) 50 (40.0) 1.81 1.11-2.94 166 (31.2) 43 (33.3) 1.23 0.80-0.96 1.46 1.06-2.00
TT 15 (4.6) 4 (3.2) 0.72 0.22-2.38 9 (1.7) 9 (7.0) 4.90 1.83-13.13 1.99 0.95-0.98
P trend 0.169 0.015 0.006
JAK3
 JAK3 rs321274110 GG 192 (58.2) 81 (64.8) 1.00 319 (59.6) 94 (72.9) 1.00 1.00
AG 119 (36.1) 40 (32.0) 0.86 0.53-1.39 196 (36.6) 31 (24.0) 0.53 0.34-0.83 0.66 0.48-0.92
AA 19 (5.8) 4 (3.2) 0.51 0.16-1.66 20 (3.7) 4 (3.1) 0.67 0.22-2.05 0.56 0.25-1.27
P trend 0.251 0.009 0.007
rs207249610 GG 270 (81.8) 92 (73.6) 1.00 438 (82.0) 100 (77.5) 1.00 1.00
AG 59 (17.9) 31 (24.8) 1.49 0.88-2.55 95 (17.8) 26 (20.2) 1.22 0.75-2.01 1.34 0.93-1.92
AA 1 (0.3) 2 (1.6) 8.22 0.44-151.78 1 (0.2) 3 (2.3) 17.6 1.76-175.30 14.2 2.38-84.78
P trend 0.061 0.080 0.010
MIF
 MIF rs738807 CC 244 (73.9) 103 (82.4) 1.00 392 (73.3) 104 (80.6) 1.00 1.00
CT 80 (24.2) 22 (17.6) 0.65 0.37-1.13 137 (25.6) 23 (17.8) 0.58 0.35-0.97 0.61 0.42-0.89
TT 6 (1.8) 0 (0.0) 0.00 23 6 (1.1) 2 (1.6) 1.52 0.29-8.09 0.53 0.11-2.57
P trend 0.028 0.093 0.007
1

Odds ratio (OR).

2

ORs adjusted for sex, age, study hospital, and distance of residence from hospital.

3

95% confidence intervals.

4

ORs adjusted for sex, age, and state of residence.

5

ORs adjusted for study, sex, residence, and age within each study.

6

D' = 1.00 and r2 = 0.06.

7

Pairwise 0.74 ≤ D' ≤1.00 and 0.52 ≤ r2 ≤0.72.

8

D' = 0.99 and r2 = 0.67.

9

Pairwise D'=1.00 and 0.42 ≤ r2 ≤0.72.

10

D' = 0.65 and r2 = 0.01. All D' and r2 are reported for pooled controls of European background.