Fig. 3.

Ingenuity® network analysis revealed primarily up-regulation of interacting pathways involved in transcription, calcium signaling, oxidative stress response and glucocorticoid receptor signaling. Red indicates up-regulation and green down-regulation of the associated genes. Genes not colored indicate no change in expression but they are highly linked to genes that did change. Solid lines indicate a direct interaction between genes, whereas dashed lines indicate an indirect interaction between the genes. [For interpretation of the references to color in this figure, the reader is referred to the web version of the article] Abbreviations used: Acta1 – actin alpha 1 skeletal muscle; Actl6a – actin-like 6A; Adam17 – a disintegrin and metallopeptidase domain 17; Adamts1 – a disintegrin-like and metallopeptidase; Apex1 – a purinic/pyrimidinic endonuclease 1; Cdc37l1 – cell division cycle 37 homolog-like 1; Cbx3 – chromobox homolog 3; Cbp/p300 – CREB binding protein; Dr1 – down-regulator of transcription 1; Ep300 – E1A binding protein p300; Gtf2a2 – general transcription factor IIA 2; Hsp70 – heat shock protein 70; Hnrpk – heterogeneous nuclear ribonucleoprotein K; Hdac2 – histone deacetylase 2; Hdac5 – histone deacetylase 5; Irf3 – interferon regulatory factor 3; Kcnq3 – potassium voltage-gated channel subfamily Q member 3; Mxl1 – Max interacting protein 1; Med4 – mediator of RNA polymerase II transcription subunit 4 homolog; Mbd1 – methyl-CpG binding domain protein 1; Mtus1 – mitochondrial tumor suppressor 1; Pi3k – phosphatidylinositol 3-kinase; Pik3c3 – phosphoinositide-3-kinase class 3; Ppp2ca – protein phosphatase 2 catalytic subunit alpha isoform; Rbbp6 – retinoblastoma binding protein 6; Rnf2 – ring finger protein 2; Rbm3 – RNA binding motif protein 3; Tceb3 – transcription elongation factor B polypeptide 3; Tpm3 – tropomyosin 3 gamma.