Table 1.

Significant Effects of Alcohol Drinking under 24-hr Continuous Access on Changes in Gene Expression in the Nucleus Accumbens of P rats

Symbol	Gene Description	CA/W	FDR q	p-value	QTL	Chr	LOD
Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	1.08	0.15	0.010
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	1.11	0.11	0.002
Acta1	actin, alpha 1, skeletal muscle	1.12	0.12	0.004
Actl6a	Actin-like 6A	1.10	0.12	0.003
Abt1	activator of basal transcription 1	1.07	0.12	0.005
---	Activity and neurotransmitter-induced early gene 1 (ania-1) mRNA, 3′UTR	1.23	0.12	0.004
Arc	activity regulated cytoskeletal-associated protein	1.53	0.01	0.000
Adamts1	a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1	1.37	0.09	0.001
Arf6	ADP-ribosylation factor 6	1.17	0.14	0.008
Arl1	ADP-ribosylation factor-like 1	1.08	0.11	0.002
Afg3l2	AFG3(ATPase family gene 3)-like 2 (yeast)	1.08	0.12	0.004
Appbp2	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	1.17	0.13	0.006
Apex1	apurinic/apyrimidinic endonuclease 1	1.07	0.15	0.011
Actr10	ARP10 actin-related protein 10 homolog (S. cerevisiae)	1.09	0.15	0.011
Btg1	B-cell translocation gene 1, anti-proliferative	1.10	0.14	0.008
Btg2	B-cell translocation gene 2, anti-proliferative	1.35	0.02	0.000
Btg2	B-cell translocation gene 2, anti-proliferative	1.66	0.00	0.000
St6gal2	Beta galactoside alpha 2,6 sialyltransferase 2	1.26	0.09	0.001
Bex1	brain expressed X-linked 1	1.09	0.13	0.006
Bckdhb	branched chain keto acid dehydrogenase E1, beta polypeptide	1.11	0.11	0.003
C1galt1c1	C1GALT1-specific chaperone 1	1.08	0.15	0.011
Cdh20	cadherin 20	1.11	0.12	0.004
Crcp	calcitonin gene-related peptide-receptor component protein	1.07	0.14	0.008	Alc10	12	2.2
Cant1	calcium activated nucleotidase 1	1.07	0.12	0.005
Cacybp	calcyclin binding protein	1.18	0.11	0.003
Chst1	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	1.13	0.15	0.011
Cdv1	carnitine deficiency-associated gene expressed in ventricle 1	1.18	0.15	0.009	Alc6	12	4.7
Cebpd	CCAAT/enhancer binding protein (C/EBP), delta	1.13	0.14	0.008
Cdc42	Cell division cycle 42 homolog (S. cerevisiae)	1.09	0.15	0.010
Cep57	centrosomal protein 57	1.11	0.15	0.010
Chrna7	Cholinergic receptor, nicotinic, alpha polypeptide 7	1.11	0.15	0.010
Cbx3	chromobox homolog 3 (HP1 gamma homolog, Drosophila)	1.09	0.11	0.003	Alc18	4	9.2
Coq3	coenzyme Q3 homolog, methyltransferase (yeast)	1.10	0.10	0.002
Cirbp	cold inducible RNA binding protein	1.16	0.14	0.008
Commd10	COMM domain containing 10	1.16	0.13	0.006
Commd3	COMM domain containing 3	1.06	0.12	0.004
Ctgf	connective tissue growth factor	1.24	0.09	0.001
Crh	corticotropin releasing hormone	1.24	0.12	0.004
Ddx21a	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21a	1.16	0.09	0.001
Dnd1	dead end homolog 1 (zebrafish)	1.13	0.10	0.001
Dhrs7b	dehydrogenase/reductase (SDR family) member 7B	1.06	0.14	0.007
Dlc1	deleted in liver cancer 1	1.14	0.11	0.003	Alc11	16	3.2
Dnttip1	deoxynucleotidyltransferase, terminal, interacting protein 1	1.09	0.13	0.006
Dld	dihydrolipoamide dehydrogenase	1.13	0.15	0.010
Dcx	doublecortin	1.20	0.14	0.007
Dr1	down-regulator of transcription 1	1.13	0.09	0.001
Dph5	DPH5 homolog (S. cerevisiae)	1.11	0.14	0.007	Alc15	2	4.1
Dsm-1	D-serine modulator-1	1.06	0.13	0.006
Dusp1	dual specificity phosphatase 1	1.42	0.00	0.000	Alc5	10	2.4
Dusp1	dual specificity phosphatase 1	1.42	0.02	0.000
Dusp6	dual specificity phosphatase 6	1.18	0.07	0.000
Dusp6	dual specificity phosphatase 6	1.13	0.10	0.001
Dusp6	Dual specificity phosphatase 6	1.13	0.14	0.008
Ep300	E1A binding protein p300	1.17	0.11	0.002
Egln3	EGL nine homolog 3 (C. elegans)	1.10	0.15	0.011
Efna3	ephrin A3	1.13	0.10	0.002
Eif2a	eukaryotic translation initiation factor 2A	1.18	0.14	0.009
Eif2s1	eukaryotic translation initiation factor 2, subunit 1 alpha	1.12	0.10	0.002
Nme1	expressed in non-metastatic cells 1	1.05	0.15	0.011
Fos	FBJ murine osteosarcoma viral oncogene homolog	1.72	0.00	0.000
Frag1	FGF receptor activating protein 1	1.13	0.14	0.007
Fkbp1b	FK506 binding protein 1b	1.14	0.09	0.001
Galk2	galactokinase 2	1.11	0.12	0.003
Gtf2a2	general transcription factor IIa 2	1.08	0.15	0.009
Gpm6a	glycoprotein m6a	1.11	0.15	0.009	Alc11	16	3.2
Gpr85	G protein-coupled receptor 85	1.11	0.12	0.005
Gdf11	growth differentiation factor 11	1.09	0.12	0.004
Grb2	growth factor receptor bound protein 2	1.07	0.11	0.003
Gng10	guanine nucleotide binding protein (G protein), gamma 10	1.08	0.12	0.003
Gucy1b3	guanylate cyclase 1, soluble, beta 3	1.09	0.15	0.010
Hes1	hairy and enhancer of split 1 (Drosophila)	1.17	0.15	0.009
Hsf2	heat shock factor 2	1.13	0.10	0.001
Havcr2	hepatitis A virus cellular receptor 2	1.18	0.15	0.010
Hnrpab	heterogeneous nuclear ribonucleoprotein A/B	1.10	0.11	0.003
Hnrpk	heterogeneous nuclear ribonucleoprotein K	1.08	0.15	0.009
Hdac2	histone deacetylase 2	1.13	0.13	0.005
Hdac5	Histone deacetylase 5	1.14	0.11	0.003
Homer1	homer homolog 1 (Drosophila)	1.71	0.01	0.000
Hrpap20	hormone-regulated proliferation associated protein 20	1.11	0.13	0.005
Hagh	hydroxyacyl glutathione hydrolase	1.09	0.14	0.007	Alc5	10	2.4
Hcn1	Hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	1.33	0.11	0.003
Ier2	immediate early response 2	1.33	0.01	0.000
Itga6	integrin, alpha 6	1.11	0.11	0.003
Itgb3bp	integrin beta 3 binding protein (beta3-endonexin)	1.14	0.12	0.004
Ift74	intraflagellar transport 74 homolog (Chlamydomonas)	1.14	0.13	0.006
Nyw1	ischemia related factor NYW-1	1.15	0.07	0.000
Idi1	isopentenyl-diphosphate delta isomerase	1.14	0.02	0.000
Icmt	isoprenylcysteine carboxyl methyltransferase	1.07	0.13	0.006
Junb	Jun-B oncogene	1.27	0.00	0.000
Jun	Jun oncogene	1.15	0.14	0.009
Jun	Jun oncogene	1.23	0.01	0.000
Kab	KARP-1 binding protein 1	1.10	0.11	0.002
Khdrbs2	KH domain containing, RNA binding, signal transduction associated 2	1.35	0.11	0.002
Kif2	kinesin heavy chain family, member 2	1.13	0.12	0.003
Lactb2	lactamase, beta 2	1.14	0.14	0.007
Lactb2	Lactamase, beta 2	1.10	0.15	0.011
Lap3	leucine aminopeptidase 3	1.20	0.15	0.010
Lrrc23	leucine rich repeat containing 23	1.15	0.13	0.006
LOC246187	liver regeneration-related protein	1.12	0.11	0.002
Mgat2	mannoside acetylglucosaminyltransferase 2	1.16	0.11	0.002
Mkks	McKusick-Kaufman syndrome protein	1.07	0.12	0.004
Med4	mediator of RNA polymerase II transcription, subunit 4 homolog (yeast)	1.11	0.12	0.004
Mtf2	metal response element binding transcription factor 2	1.39	0.13	0.005
Mtx2	metaxin 2	1.16	0.10	0.001
Mbd1	Methyl-CpG binding domain protein 1	1.12	0.14	0.008
Mtfmt	mitochondrial methionyl-tRNA formyltransferase	1.10	0.14	0.008
Mcl1	myeloid cell leukemia sequence 1	1.14	0.14	0.007
Mx2	myxovirus (influenza virus) resistance 2	1.21	0.04	0.000
Ndufa9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9	1.17	0.11	0.003
Ndufv3l	NADH dehydrogenase (ubiquinone) flavoprotein 3-like	1.13	0.12	0.004
LOC493574	notch1-induced protein	1.24	0.11	0.003
Nip7	nuclear import 7 homolog (S. cerevisiae)	1.15	0.09	0.001
Nrbf2	nuclear receptor binding factor 2	1.15	0.09	0.001
Nr4a1	nuclear receptor subfamily 4, group A, member 1	1.62	0.00	0.000
Nr4a3	nuclear receptor subfamily 4, group A, member 3	1.46	0.04	0.000
Nup155	Nucleoporin 155	1.13	0.14	0.008
Nupl1	nucleoporin like 1	1.15	0.11	0.003
Nap1l2	nucleosome assembly protein 1-like 2	1.25	0.14	0.007
Nap1l3	nucleosome assembly protein 1-like 3	1.17	0.10	0.001
Numbl	Numb-like	1.16	0.15	0.010
Orc6l	origin recognition complex, subunit 6-like (S. cerevisiae)	1.20	0.04	0.000
Orc6l	origin recognition complex, subunit 6-like (S. cerevisiae)	1.22	0.12	0.004
Pspc1	paraspeckle protein 1	1.13	0.15	0.010
Psip1	PC4 and SFRS1 interacting protein 1	1.39	0.08	0.000
Ppig	peptidylprolyl isomerase G	1.22	0.10	0.001
Phf12	PHD finger protein 12	1.10	0.12	0.004
Phf12	PHD finger protein 12	1.12	0.15	0.010
Pigk	phosphatidylinositol glycan, class K	1.10	0.14	0.008
Pfkl	phosphofructokinase, liver, B-type	1.11	0.15	0.010
Pgam5	phosphoglycerate mutase family member 5	1.10	0.11	0.003
Pik3c3	phosphoinositide-3-kinase, class 3	1.07	0.13	0.005
Plaa	phospholipase A2, activating protein	1.12	0.11	0.002
Ppcs	phosphopantothenoylcysteine synthetase	1.08	0.15	0.009
Prps2	phosphoribosyl pyrophosphate synthetase 2	1.22	0.09	0.001
Prpsap2	phosphoribosyl pyrophosphate synthetase-associated protein 2	1.11	0.10	0.001
Psph	phosphoserine phosphatase	1.13	0.13	0.005	Alc10	12	2.2
Plagl1	pleiomorphic adenoma gene-like 1	1.14	0.14	0.008
Pcyox1	prenylcysteine oxidase 1	1.20	0.11	0.002	Alc18	4	9.2
Pnrc1	proline rich 2	1.16	0.11	0.003
Psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	1.28	0.09	0.001
Psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	1.21	0.03	0.000
Psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	1.20	0.09	0.001
Psmd12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	1.12	0.10	0.001
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	1.07	0.12	0.003
Psma4	proteasome (prosome, macropain) subunit, alpha type 4	1.09	0.09	0.001
Pkib	protein kinase inhibitor beta, cAMP dependent, catalytic	1.23	0.11	0.003
Pkib	protein kinase inhibitor beta, cAMP dependent, catalytic	1.36	0.15	0.010
Prkra	protein kinase, interferon inducible double stranded RNA dependent activator	1.11	0.12	0.004
Pofut1	Protein O-fucosyltransferase 1	1.13	0.15	0.010
Ppp2ca	Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	1.20	0.08	0.000
Ppp2ca	Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	1.10	0.04	0.000
Pcdha1 /// Pcdha10 /// Pcdha11 /// Pcdha12 /// Pcdha13 /// Pcdha2 /// Pcdha3 protocadherin alpha 4 /// protocadherin alpha 13 /// protocadher i/n// aPlpcdhhaa 140 / // /P pcrdohtoac5a /d/h/ ePrcind haalp6h		1.15	0.15	0.010
P2ry2	purinergic receptor P2Y, G-protein coupled 2	1.13	0.10	0.002
LOC289809	putatative 28 kDa protein	1.24	0.10	0.001
Rab1	RAB1, member RAS oncogene family	1.10	0.14	0.007
Rab21	RAB21, member RAS oncogene family	1.14	0.14	0.007
Rab35	RAB35, member RAS oncogene family	1.14	0.13	0.006
Rab3c	RAB3C, member RAS oncogene family	1.11	0.14	0.007
Rad17	RAD17 homolog (S. pombe)	1.13	0.11	0.003
Rdx	Radixin	1.12	0.12	0.003
Rae1	RAE1 RNA export 1 homolog (S. pombe)	1.07	0.14	0.008
Ripx	rap2 interacting protein x	1.12	0.10	0.001
Rdbp	RD RNA-binding protein	1.09	0.10	0.001
Rcn2	reticulocalbin 2	1.14	0.10	0.002
Rbbp6	Retinoblastoma binding protein 6	1.17	0.12	0.003
Rnf149	ring finger protein 149	1.15	0.14	0.007
Rnf2	ring finger protein 2	1.14	0.13	0.005
---	RM2 mRNA, partial sequence	1.39	0.04	0.000
Rbm13	RNA binding motif protein 13	1.13	0.14	0.007
Rbm14	RNA binding motif protein 14	1.11	0.15	0.011
Rbm17	RNA binding motif protein 17	1.08	0.14	0.007
Rbm3	RNA binding motif protein 3	1.14	0.11	0.002
Rg9mtd1	RNA (guanine-9-) methyltransferase domain containing 1	1.10	0.14	0.008
Rpo1-1	RNA polymerase 1-1	1.08	0.15	0.011
Rwdd3	RWD domain containing 3	1.18	0.14	0.008	Alc15	2	4.1
Rwdd3	RWD domain containing 3	1.17	0.14	0.009
Sec23ip	SEC23 interacting protein	1.06	0.15	0.009
Scg2	secretogranin 2	1.12	0.13	0.006
Siah1a	seven in absentia 1A	1.13	0.14	0.007
Siah2	seven in absentia 2	1.13	0.12	0.004
Srp54	signal recognition particle 54	1.16	0.12	0.004
Six3	Sine oculis homeobox homolog 3 (Drosophila)	1.19	0.13	0.006	Alc17	6	3.1
Ssbp1	single-stranded DNA binding protein 1	1.16	0.09	0.001	Alc18	4	9.2
Ssbp1	single-stranded DNA binding protein 1	1.15	0.09	0.001
Scye1	small inducible cytokine subfamily E, member 1	1.08	0.15	0.011	Alc15	2	4.1
Slc4a10	Solute carrier family 4, sodium bicarbonate transporter-like, member 10	1.15	0.14	0.007
Slc6a15	solute carrier family 6 (neurotransmitter transporter), member 15	1.10	0.14	0.009
Snx16	sorting nexin 16	1.13	0.13	0.006
Snx16	sorting nexin 16	1.13	0.11	0.003
Spg3a	spastic paraplegia 3A homolog (human)	1.12	0.11	0.003
Spdy1	speedy homolog 1 (Drosophila)	1.17	0.14	0.007	Alc17	6	3.1
Sf4	splicing factor 4	1.09	0.14	0.009	Alc11	16	3.2
Spon1	spondin 1	1.12	0.10	0.001
Spry2	sprouty homolog 2 (Drosophila)	1.10	0.15	0.011
Sod2	superoxide dismutase 2, mitochondrial	1.14	0.10	0.001
Syncrip	Synaptotagmin binding, cytoplasmic RNA interacting protein	1.19	0.15	0.010
Taf9l	TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa	1.21	0.11	0.002
Tfpt	TCF3 (E2A) fusion partner	1.11	0.11	0.003
Tcp11l2	t-complex 11 (mouse) like 2	1.11	0.14	0.007
Tgif	TG interacting factor	1.21	0.02	0.000
Txnl1	thioredoxin-like 1	1.13	0.14	0.008
Txnl2	thioredoxin-like 2	1.08	0.15	0.010
Tmsbl1	thymosin beta-like protein 1	1.22	0.11	0.003
Tceal8	transcription elongation factor A (SII)-like 8	1.09	0.13	0.006
Tceb3	Transcription elongation factor B (SIII), polypeptide 3	1.10	0.10	0.002
Tgfa	transforming growth factor alpha	1.13	0.14	0.008	Alc18	4	9.2
Tgfa	transforming growth factor alpha	1.14	0.15	0.010
Tomm20	translocase of outer mitochondrial membrane 20 homolog (yeast)	1.07	0.12	0.005
Tmem17	transmembrane protein 17	1.10	0.12	0.003
Tmeff1	transmembrane protein with EGF-like and two follistatin-like domains 1	1.13	0.11	0.002
Tpm3	tropomyosin 3, gamma	1.11	0.07	0.000
Tpm3	tropomyosin 3, gamma	1.15	0.15	0.010
Tubb2b	tubulin, beta 2b	1.10	0.10	0.001
Uchl5	ubiquitin carboxyl-terminal hydrolase L5	1.11	0.04	0.000
Ube2d2	ubiquitin-conjugating enzyme E2D 2	1.17	0.14	0.007
Ube2d3	Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	1.07	0.14	0.007	Alc15	2	4.1
LOC500954	Ubiquitin-Like 5 Protein	1.12	0.09	0.001
Ufc1	Ufm1-conjugating enzyme 1	1.07	0.13	0.005
Vps33a	vacuolar protein sorting 33A (yeast)	1.21	0.13	0.006	Alc6	12	4.7
Vkorc1l1	vitamin K epoxide reductase complex, subunit 1-like 1	1.14	0.10	0.001
Wdfy1	WD repeat and FYVE domain containing 1	1.11	0.11	0.003
Wdr39	WD repeat domain 39	1.08	0.14	0.009
Wdr77	WD repeat domain 77	1.18	0.11	0.002	Alc15	2	4.1
Wdr77	WD repeat domain 77	1.12	0.10	0.001
Wrnip1	Werner helicase interacting protein 1	1.12	0.11	0.003
Zcchc10	zinc finger, CCHC domain containing 10	1.11	0.10	0.001
Zcrb1	zinc finger CCHC-type and RNA binding motif 1	1.20	0.10	0.001
Zipro1	zinc finger proliferation 1	1.14	0.12	0.004
Zfp297	zinc finger protein 297	1.09	0.15	0.010
Zfp367	zinc finger protein 367	1.18	0.12	0.004
Zfp403	zinc finger protein 403	1.15	0.14	0.009
Zfp451	zinc finger protein 451	1.10	0.15	0.010
Zfp91	zinc finger protein 91	1.13	0.09	0.001
Htr4	5-hydroxytryptamine (serotonin) receptor 4	-1.14	0.11	0.002
Nt5e	5′ nucleotidase, ecto	-1.15	0.10	0.002
Actn1	actinin, alpha 1	-1.12	0.09	0.001
Actn1	Actinin, alpha 1	-1.16	0.14	0.007
Apeh	acylpeptide hydrolase	-1.07	0.15	0.011
Adam17	a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)	-1.08	0.15	0.010
Akap8l	A kinase (PRKA) anchor protein 8-like	-1.12	0.15	0.010
Aldh6a1	aldehyde dehydrogenase family 6, subfamily A1	-1.13	0.10	0.001
Amt	aminomethyltransferase (glycine cleavage system protein T)	-1.10	0.12	0.004
Angptl4	angiopoietin-like 4	-1.24	0.01	0.000
Armc5	armadillo repeat containing 5	-1.11	0.10	0.002
Aspa	aspartoacylase	-1.17	0.13	0.005
Atp6v0e1	ATPase, H+ transporting, V0 subunit E isoform 1	-1.13	0.14	0.009	Alc5	10	2.4
Abcg2	ATP-binding cassette, sub-family G (WHITE), member 2	-1.14	0.13	0.006	Alc18	4	9.2
St6gal1	beta galactoside alpha 2,6 sialyltransferase 1	-1.15	0.14	0.007
Cast	calpastatin	-1.10	0.15	0.010
Cml3	camello-like 3	-1.16	0.02	0.000	Alc18	4	9.2
Creb3l2	cAMP responsive element binding protein 3-like 2	-1.17	0.02	0.000	Alc18	4	9.2
Car11	carbonic anhydrase 11	-1.10	0.11	0.002
Cpt1c	carnitine palmitoyltransferase 1c	-1.09	0.14	0.009
Csnk1g1	casein kinase 1, gamma 1	-1.13	0.12	0.005
Catna1	catenin (cadherin-associated protein), alpha 1	-1.08	0.14	0.009
Cav	caveolin	-1.18	0.13	0.005
Cav2	caveolin 2	-1.19	0.11	0.002
Cd97	CD97 antigen	-1.22	0.08	0.000
Cdc37l1	cell division cycle 37 homolog (S. cerevisiae)-like 1	-1.07	0.14	0.007
Ccr5	Chemokine (C-C motif) receptor 5	-1.11	0.12	0.004
Cldn1	claudin 1	-1.15	0.15	0.011
Cldn5	claudin 5	-1.16	0.11	0.002
Creld2	cysteine-rich with EGF-like domains 2	-1.10	0.12	0.004
Cyp4f2	cytochrome P450, family 4, subfamily F, polypeptide 2	-1.11	0.11	0.002
Dock9	dedicator of cytokinesis 9	-1.21	0.10	0.001
Degs2	degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase	-1.16	0.07	0.000
Dhrs3	dehydrogenase/reductase (SDR family) member 3	-1.18	0.11	0.003
Dsp	desmoplakin	-1.15	0.10	0.002
Dgka	diacylglycerol kinase, alpha	-1.12	0.15	0.009
Dlgap2	Discs, large (Drosophila) homolog-associated protein 2	-1.26	0.11	0.002
Dlgh1	Discs, large homolog 1 (Drosophila)	-1.09	0.09	0.001
Dscr1l1	Down syndrome critical region gene 1-like 1	-1.18	0.05	0.000
Dscr1l1	Down syndrome critical region gene 1-like 1	-1.19	0.11	0.003
Eltd1	EGF, latrophilin and seven transmembrane domain containing 1	-1.29	0.01	0.000
Ehd2	EH-domain containing 2	-1.27	0.09	0.001
Ecam	endothelial cell adhesion molecule	-1.18	0.07	0.000	Alc20	8	2
Tek	endothelial-specific receptor tyrosine kinase	-1.13	0.15	0.009
Ece1	endothelin converting enzyme 1	-1.10	0.13	0.005
Epim	epimorphin	-1.14	0.14	0.008	Alc10	12	2.2
Epn2	epsin 2	-1.09	0.14	0.009
Eef2k	Eukaryotic elongation factor-2 kinase	-1.11	0.14	0.007
Ecm1	extracellular matrix protein 1	-1.19	0.13	0.005
Fbxl20	F-box and leucine-rich repeat protein 20	-1.09	0.15	0.010
Fkbp5	FK506 binding protein 5	-1.14	0.10	0.001
Fkbp5	FK506 binding protein 5	-1.18	0.07	0.000
Fmo2	flavin containing monooxygenase 2	-1.25	0.12	0.003
Foxo1a	Forkhead box O1A	-1.15	0.13	0.006
Fut2	fucosyltransferase 2 (secretor status included)	-1.15	0.13	0.005
Galt	galactose-1-phosphate uridyl transferase	-1.08	0.11	0.003
Gja1	gap junction membrane channel protein alpha 1	-1.11	0.15	0.010
Gpt1	glutamic pyruvic transaminase 1, soluble	-1.10	0.11	0.002
Gpd1	glycerol-3-phosphate dehydrogenase 1 (soluble)	-1.22	0.10	0.001
Gpd1	glycerol-3-phosphate dehydrogenase 1 (soluble)	-1.18	0.10	0.001
Gramd3	GRAM domain containing 3	-1.09	0.15	0.011
Gramd3	GRAM domain containing 3	-1.13	0.11	0.003
Garnl1	GTPase activating RANGAP domain-like 1	-1.25	0.12	0.004
Gimap6	GTPase, IMAP family member 6	-1.11	0.11	0.003	Alc18	4	9.2
Gng7	guanine nucleotide binding protein, gamma 7	-1.12	0.15	0.010
Hspa5	heat shock 70kDa protein 5 (glucose-regulated protein)	-1.10	0.11	0.002	Alc8	3	2.7
Hspa1b	heat shock 70kD protein 1B (mapped)	-1.28	0.15	0.010
Hbp1	high mobility group box transcription factor 1	-1.07	0.15	0.010
Homer1	homer homolog 1 (Drosophila)	-1.72	0.00	0.000
Hip1	huntingtin interacting protein 1	-1.14	0.10	0.002	Alc10	12	2.2
Hdh	Huntington disease gene homolog	-1.15	0.11	0.002
Hyal2	hyaluronoglucosaminidase 2	-1.17	0.09	0.001
Igj	immunoglobulin joining chain	-1.11	0.15	0.009
Irs3	insulin receptor substrate 3	-1.14	0.09	0.001
Ifngr1	interferon gamma receptor 1	-1.07	0.15	0.010
Irf3	interferon regulatory factor 3	-1.11	0.12	0.004
Il16	interleukin 16	-1.09	0.13	0.005
Nyw1	ischemia related factor NYW-1	-1.14	0.11	0.002
Jam2	junction adhesion molecule 2	-1.13	0.14	0.008
Kif11	kinesin family member 11	-1.12	0.12	0.005
Kif1b	Kinesin family member 1B	-1.10	0.15	0.010
Kif6	kinesin family member 6	-1.09	0.14	0.009
Klc1	kinesin light chain 1	-1.08	0.14	0.008
Lphn2	latrophilin 2	-1.08	0.14	0.007
Leng8	leukocyte receptor cluster (LRC) member 8	-1.12	0.14	0.006
Lims2	LIM and senescent cell antigen like domains 2	-1.23	0.01	0.000
LMO7	LIM domain only protein 7	-1.19	0.12	0.004
Lcn7	lipocalin 7	-1.24	0.09	0.001
Lsr	lipolysis stimulated lipoprotein receptor	-1.21	0.14	0.006
Lef1	Lymphoid enhancer binding factor 1	-1.12	0.09	0.001	Alc15	2	4.1
Man2a1	mannosidase 2, alpha 1	-1.16	0.09	0.001
Mcpt1	mast cell protease 1	-1.14	0.10	0.001
Mxi1	Max interacting protein 1	-1.07	0.14	0.008
Mbc2	membrane bound C2 domain containing protein	-1.15	0.14	0.008
Mpp4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	-1.08	0.12	0.005
Mgea5	Meningioma expressed antigen 5 (hyaluronidase)	-1.14	0.11	0.003
Mat2a	methionine adenosyltransferase II, alpha	-1.11	0.14	0.007
Mettl7b	methyltransferase like 7B	-1.12	0.12	0.004
Mtus1	mitochondrial tumor suppressor 1	-1.09	0.13	0.005	Alc11	16	3.2
Mobp	myelin-associated oligodendrocytic basic protein	-1.22	0.10	0.001
Ntrk2	Neurotrophic tyrosine kinase, receptor, type 2	-1.67	0.00	0.000
Nexn	nexilin	-1.15	0.14	0.008
Ng3	Ng3 protein	-1.11	0.11	0.003
Nmnat1	nicotinamide nucleotide adenylyltransferase 1	-1.11	0.15	0.011
Nos3	nitric oxide synthase 3, endothelial cell	-1.21	0.11	0.003
Nxf1	nuclear RNA export factor 1	-1.08	0.14	0.007
Numb	numb gene homolog (Drosophila)	-1.12	0.12	0.004
Ocln	occludin	-1.14	0.10	0.002
Pthr1	Parathyroid hormone receptor 1	-1.20	0.07	0.000
Per2	period homolog 2 (Drosophila)	-1.17	0.04	0.000
Ppap2b	phosphatidic acid phosphatase type 2B	-1.12	0.11	0.002
Plce1	phospholipase C, epsilon 1	-1.12	0.14	0.009
Plcg1	phospholipase C, gamma 1	-1.12	0.12	0.004
RGD1303232	Phytn_dehydro and Pyr_redox domain containing protein RGD1303232	-1.10	0.13	0.006
Pkp2	plakophilin 2	-1.14	0.10	0.001
Podxl	podocalyxin-like	-1.11	0.12	0.004	Alc18	4	9.2
Pola2	Polymerase (DNA directed), alpha 2	-1.16	0.13	0.005
Polm	polymerase (DNA directed), mu	-1.11	0.13	0.006
Kcnt1	potassium channel, subfamily T, member 1	-1.12	0.14	0.008	Alc8	3	2.7
Kcnq3	Potassium voltage-gated channel, subfamily Q, member 3	-1.22	0.10	0.001
Plod1	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	-1.13	0.15	0.009
Col4a1	procollagen, type IV, alpha 1	-1.14	0.12	0.004
Psrc2	proline/serine-rich coiled-coil 2	-1.07	0.14	0.008
Pcsk7	proprotein convertase subtilisin/kexin type 7	-1.11	0.11	0.003
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	-1.08	0.15	0.009
Ptprg	Protein tyrosine phosphatase, receptor type, G	-1.15	0.10	0.001
Ptprv	protein tyrosine phosphatase, receptor type, V	-1.10	0.14	0.007
Pxk	PX domain containing serine/threonine kinase	-1.08	0.13	0.006
Rad9b	RAD9 homolog B (S. cerevisiae)	-1.19	0.11	0.002	Alc6	12	4.7
Ralgds	ral guanine nucleotide dissociation stimulator	-1.16	0.09	0.001	Alc8	3	2.7
Rap1ga1	RAP1, GTPase activating protein 1	-1.11	0.14	0.007
Rasd2	RASD family, member 2	-1.17	0.10	0.001
Rasd2	RASD family, member 2	-1.20	0.08	0.000
Rasgrp4	RAS guanyl releasing protein 4	-1.16	0.07	0.000
Ramp2	receptor (calcitonin) activity modifying protein 2	-1.11	0.13	0.006
Rgs8	regulator of G-protein signaling 8	-1.12	0.14	0.008
Rgs9	regulator of G-protein signaling 9	-1.15	0.11	0.002
Rgs3	Regulator of G-protein signalling 3	-1.12	0.14	0.007
Rcn2	Reticulocalbin 2	-1.10	0.12	0.004
Arhgap17	Rho GTPase activating protein 17	-1.09	0.13	0.006
Serpina1	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	-1.12	0.14	0.009
Shank1	SH3 and multiple ankyrin repeat domains 1	-1.14	0.15	0.010
Cr16	SH3 domain binding protein CR16	-1.13	0.13	0.005	Alc18	4	9.2
Sipa1l1	Signal-induced proliferation-associated 1 like 1	-1.21	0.04	0.000
Srpr	signal recognition particle receptor (‘docking protein’)	-1.10	0.15	0.010	Alc20	8	2
Stat4	signal transducer and activator of transcription 4	-1.18	0.12	0.004
Smr2	SMR2	-1.12	0.15	0.010
Slc14a2	solute carrier family 14 (urea transporter), member 2	-1.21	0.11	0.003
Slc29a1	solute carrier family 29 (nucleoside transporters), member 1	-1.10	0.10	0.002
Slc2a1	solute carrier family 2 (facilitated glucose transporter), member 1	-1.16	0.04	0.000
Slc9a3r2	Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2	-1.14	0.07	0.000	Alc5	10	2.4
Slco2b1	solute carrier organic anion transporter family, member 2b1	-1.16	0.11	0.002
Sox18	SRY-box containing gene 18	-1.16	0.12	0.005
Sts	steroid sulfatase	-1.11	0.12	0.003
Stom	stomatin	-1.13	0.14	0.007	Alc8	3	2.7
Sulf2	Sulfatase 2	-1.13	0.14	0.007
Sdc1	syndecan 1	-1.13	0.10	0.002	Alc17	6	3.1
Tec	tec protein tyrosine kinase	-1.09	0.15	0.011
Ttc7	tetratricopeptide repeat domain 7	-1.12	0.14	0.006	Alc17	6	3.1
Tef	thyrotroph embryonic factor	-1.14	0.14	0.008
pur-beta	Transcription factor Pur-beta	-1.13	0.15	0.009
Tgfbr3	transforming growth factor, beta receptor III	-1.14	0.13	0.005
Tmed7	Transmembrane emp24 protein transport domain containing 7	-1.11	0.15	0.010
Tsc22d3	TSC22 domain family 3	-1.10	0.09	0.001
Tyrp1	tyrosinase-related protein 1	-1.13	0.12	0.004
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	-1.21	0.10	0.002
Ubadc1	Ubiquitin associated domain containing 1	-1.11	0.15	0.010	Alc8	3	2
Utrn	utrophin	-1.10	0.09	0.001
Vamp1	vesicle-associated membrane protein 1	-1.12	0.13	0.005
Vwa1	von Willebrand factor A domain containing 1	-1.13	0.12	0.004
Wnk4	WNK lysine deficient protein kinase 4	-1.21	0.02	0.000
Wbp1	WW domain binding protein 1	-1.08	0.12	0.004	Alc18	4	9.2
Wbp1	WW domain binding protein 1	-1.08	0.14	0.008

CA/W = fold change of continuous access group to water group; Chr = chromosome number; QTL = rat alcohol preference QTL; LOD = LOD score for QTL; Bold type indicates genes in common with MSA vs. W differences.