Table 1.
High-frequency deviations and minimally overlapping regions (MOR) in CR tumors. Losses (A) and gains (B) are listed separately. High-frequency is defined as observed with an adjusted frequency of ≥30%. The start position, size, and any constituent MORs observed at higher frequency than the larger deviation are given for each deviation. Mbp positions are rounded to nearest 0.1 Mbp. MORs observed at ≥50% are in bold. The start site and size of CR-associated alterations are given.
| A. Losses | B. Gains | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Deviation |
MOR |
CR-associated |
Deviation |
MOR |
CR-associated |
||||||||||
| Band | Start (Mbp) |
Size (Mbp) |
(%) | Start (Mbp) |
Size (Mbp) |
Start (Mbp) |
Size (Mbp) |
Band | Start (Mbp) |
Size (Mbp) |
(%) | Start (Mbp) |
Size (Mbp) |
Start (Mbp) |
Size (Mbp) |
| 1p36.23-p35.1 | 7.2 | 25.2 | 36 | 16.3 | 3.5 | 7.2 | 25.2 | 1p12-q43 | 120.0 | 117.7 | 65 | 147.9 | 2.8 | 153.6 | 84.3 |
| 43 | 26.7 | 2.5 | 52 | 155.2 | 0.7 | ||||||||||
| 1p33-p32.3 | 48.4 | 6.8 | 49 | 157.6 | 6.9 | ||||||||||
| 2q37.3 | 238.6 | 3.7 | 238.6 | 3.7 | 55 | 200.3 | 1.9 | ||||||||
| 3p21.31 | 46.3 | 1.8 | 31 | 46.3 | 0.6 | 46.3 | 1.8 | 45 | 209.4 | 3.0 | |||||
| 4p16.3-p16.1 | 0.1 | 10.6 | 38 | 2.7 | 0.3 | 0.1 | 4.4 | 1q41–43 | 215.6 | 22.1 | 33 | 220.4 | 7.6 | ||
| 5.1 | 5.6 | 2p25.1 | 9.6 | 1.8 | 33 | 9.5 | 1.2 | ||||||||
| 4q33-q34.3 | 171.7 | 9.9 | 35 | 175.5 | 3.5 | 171.7 | 9.9 | 5q31.3 | 140.1 | 0.8 | |||||
| 4q34.3-q35.2 | 182.2 | 8.2 | 37 | 184.3 | 0.9 | 182.2 | 5.2 | 7p22.3-q36.3 | 0.1 | 158.5 | 47 | 5.5 | 0.5 | 6.4 | 16.4 |
| 38 | 188.0 | 2.4 | 45 | 26.8 | 2.5 | 27.7 | 44.2 | ||||||||
| 5q11.2-q13.2 | 55.1 | 15.9 | 42 | 55.3 | 7.5 | 47 | 62.0 | 4.0 | 75.3 | 23.6 | |||||
| 40 | 67.8 | 2.4 | 55 | 72.6 | 2.6 | 105.6 | 42.1 | ||||||||
| 5q14.2-q22.2 | 81.7 | 31.0 | 39 | 96.0 | 13.7 | 55 | 78.9 | 1.3 | |||||||
| 5q23.1-q23.2 | 115.4 | 11.8 | 35 | 117.6 | 7.3 | 53 | 99.1 | 3.1 | |||||||
| 5q34-q35.2 | 160.7 | 15.6 | 37 | 165.0 | 6.1 | 171.3 | 5.0 | 44 | 121.3 | 5.4 | |||||
| 6p25.3-p22.3 | 0.2 | 21.5 | 39 | 12.3 | 1.2 | 5.8 | 9.1 | 46 | 128.7 | 0.8 | |||||
| 6q13-q22.31 | 75.2 | 43.7 | 43 | 88.7 | 5.2 | 48 | 136.2 | 0.4 | |||||||
| 36 | 103.9 | 9.8 | 50 | 148.2 | 5.2 | ||||||||||
| 8p23.3-p11.21 | 0.3 | 40.3 | 67 | 1.5 | 1.7 | 8p12-q24.3 | 36.5 | 109.6 | 64 | 43.3 | 6.0 | 42.9 | 103.2 | ||
| 66 | 4.6 | 1.6 | 69 | 57.2 | 8.2 | ||||||||||
| 74 | 19.8 | 3.5 | 81 | 79.3 | 0.5 | ||||||||||
| 71 | 25.5 | 1.8 | 82 | 93.3 | 6.0 | ||||||||||
| 10p15.3-q26.3 | 0.2 | 135.1 | 39 | 0.2 | 0.1 | 0.2 | 42.6 | 79 | 102.3 | 2.5 | |||||
| 47 | 9.0 | 3.3 | 50.4 | 25.7 | 78 | 115.1 | 6.5 | ||||||||
| 44 | 32.4 | 2.8 | 79.1 | 15.7 | 73 | 131.1 | 2.4 | ||||||||
| 42 | 43.0 | 1.0 | 95.9 | 39.4 | 9q33.2 | 122.4 | 1.1 | ||||||||
| 52 | 72.0 | 2.4 | 9q33.2-q33.3 | 124.3 | 3.8 | 33 | 124.6 | 1.1 | |||||||
| 86 | 89.4 | 1.2 | 9q34.11 | 129.5 | 0.8 | ||||||||||
| 68 | 98.2 | 3.7 | 11q12.1-q24.1 | 59.4 | 63.0 | 42 | 65.8 | 1.2 | 77.5 | 39.5 | |||||
| 68 | 103.4 | 0.4 | 41 | 73.5 | 1.3 | ||||||||||
| 79 | 105.9 | 5.0 | 39 | 83.8 | 18.4 | ||||||||||
| 68 | 121.7 | 6.9 | 40 | 105.3 | 4.2 | ||||||||||
| 11p15.4 | 4.2 | 0.3 | 33 | 117.8 | 0.4 | ||||||||||
| 13q11-q34 | 18.4 | 95.0 | 50 | 18.4 | 4.4 | 18.4 | 9.7 | 11q23.3-q24.1 | 119.0 | 3.4 | |||||
| 45 | 27.0 | 1.1 | 97.2 | 16.2 | 11q24.1-q24.2 | 123.1 | 2.7 | 32 | 123.1 | 2.3 | 123.1 | 2.3 | |||
| 80 | 40.6 | 0.8 | 12q24.31-q24.32 | 119.8 | 4.8 | 33 | 119.8 | 2.8 | |||||||
| 85 | 44.6 | 3.1 | 16p13.3 | 0.9 | 2.4 | ||||||||||
| 64 | 52.1 | 0.1 | 16p12.1-p11.1 | 27.6 | 6.9 | 35 | 29.7 | 4.8 | |||||||
| 63 | 72.4 | 2.6 | 18p11.32 | 0.2 | 2.0 | ||||||||||
| 59 | 101.3 | 2.8 | Xp22.31-p22.12 | 7.5 | 11.8 | ||||||||||
| 15q24.3-q25.1 | 75.1 | 1.9 | 71.4 | 13.9 | Xp11.22-q13.1 | 51.5 | 16.5 | 50 | 65.1 | 2.8 | 65.1 | 2.8 | |||
| 15q25.1-q26.3 | 78.7 | 21.3 | 40 | 85.4 | 7.4 | 86.5 | 4.1 | ||||||||
| 96.6 | 3.4 | ||||||||||||||
| 16q11.2-q24.3 | 45.3 | 43.3 | 57 | 49.4 | 5.3 | 55.0 | 4.3 | ||||||||
| 47 | 63.6 | 0.2 | 65.0 | 2.2 | |||||||||||
| 82 | 80.7 | 1.6 | 82.4 | 6.2 | |||||||||||
| 17p13.3-p11.2 | 0.1 | 19.5 | 51 | 0.1 | 0.5 | 0.1 | 15.2 | ||||||||
| 61 | 7.6 | 0.3 | 15.4 | 4.2 | |||||||||||
| 17q24.2-q25.3 | 64.6 | 8.9 | 41 | 66.1 | 2.6 | 64.6 | 8.9 | ||||||||
| 17q25.3 | 74.4 | 1.6 | 73.8 | 2.1 | |||||||||||
| 18q12.1-q23 | 28.2 | 47.9 | 75.4 | 0.7 | |||||||||||
| 19p12-q13.11 | 19.9 | 20.3 | 40 | 34.3 | 2.2 | ||||||||||
| 19q13.2-q13.31 | 46.1 | 2.5 | 36 | 47.4 | 0.6 | 46.1 | 2.5 | ||||||||
| 21q22.2-q22.3 | 38.7 | 4.5 | 38 | 38.7 | 3.0 | ||||||||||
| 22q11.1-q13.33 | 16.2 | 33.2 | 65 | 24.6 | 1.6 | 16.2 | 8.2 | ||||||||
| 46 | 43.4 | 6.0 | 26.7 | 23.2 | |||||||||||
Abbreviations: “Chr.” = chromosome, “Min”. = the minimum observed frequency for the larger deviation, and “MOR (%)”= the peak frequency that defines the MOR.