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This graph shows the infarct size (ratio of infarct to ischemic area) according to ALA dose at 45 minutes after reperfusion by propidium iodide fluorescence. The ALA at doses of 25 mg/kg (p<0.0001), 50 mg/kg (p<0.05), and 100 mg/kg (p<0.05) significantly reduced the infarct size compared to the control group, but not the ALA 10 mg/kg (p=0.192) group. The ALA 25 mg/kg group had the smallest infarct size. ALA: alpha-lipoic acid.
