Table 1.
S100A1 Target Proteins and Functions
| S100A1 Target | Biological Function of S100A1 | Ref. |
|---|---|---|
| Ryanodine Receptor | Increases SR calcium release | [57, 91] |
| SERCA/PLB | Increases calcium reuptake | [74] |
| PKA-R(IIb) | Influences L-type calcium channel activation | [77] |
| Tubulin | Increases microtubule stability | [61, 92, 93] |
| GFAP | Blocks intermediate filament assemblies | [92, 94] |
| Synapsin I | Inhibits F-actin bundling | [95] |
| RAGE receptor | Growth factor | [96] |
| PEVK | Passive tension modulator | [97] |
| CapZ | Unknown | [41] |
| Phosphoglucomutase | inhibits phosphoglucomutase activity | [17] |
| Membrane-associated guanylate cyclase | Stimulates guanylate cyclase | [98] |
| Annexin IV | Regulates annexin function | [94, 99] |
| Twitchin | Increases kinase activity | [100] |
| Myo D | Inhibits myoD function/phosphorylation | [101] |
| Other S100 proteins | Unknown | [40, 45, 102] |
| β-adrenergic receptor | Involved in calcium cycling | [82] |
| PKC | PKC signaling alteration | [103] |
| HSP 70 | Member of the Hsp70/Hsp90 chaperone complex | [62] |
| HSP 90 | Member of the Hsp70/Hsp90 chaperone complex | [62] |
| FKBP52 | Member of the Hsp70/Hsp90 chaperone complex | [62] |
| CyP40 | Member of the Hsp70/Hsp90 chaperone complex | [62] |
| Aldolase | Possible chaperone/folding partner | [62] |
| citrate synthase | Possible chaperone/folding partner | [62] |
| glyceraldehyde-3-phos-phate dehydrogenase | Possible chaperone/folding partner | [62] |
| Rhodanese | Possible chaperone/folding partner | [62] |
| ERK1/2 | Anti-apoptotic effector | [104] |
| CacyBP/SIP | Modulates ubiquitylation | [105] |
| p53 | Inhibits cell repair | [92] |