Figure 2. NO-np killed MRSA in subcutaneous abscesses.

(A) Abscess bacterial burden (CFU; colony forming units) in mice infected subcutaneously with 10⁷ MRSA and treated with NO-np is significantly lower than untreated or np-treated mice (n = 20 abscesses per group). Each point represents an abscess. Dashed lines are the averages of the results and error bars denote standard deviations. Asterisks denote P value significance (** P<0.001) calculated by analysis of variance and adjusted by use of the Bonferroni correction. (B) Histological analysis of Balb/c mice untreated MRSA-infected, np-treated MRSA-infected, and MRSA-infected treated with NO, day 4. Mice were infected with 10⁷ MRSA. Representative H&E-stained sections of the skin lesions are shown with the Insets showing Gram staining of MRSA. Scale bars: 25 µm.