Table 2. Association between DECTIN-1 genotypes and clinical characteristics in a subset of Crohn's disease patients from whom detailed phenotypic data were available (N = 778).
| Characteristic | Total cohort CD | (%) | T/T | (%) | T/G | (%) | G/G | (%) | Odds ratio* | 95% CI* | |
| Mean age at diagnosis, yr (SD) | 29.58 (±12.29) | 29.37 (±12.64) | 30.76 (±17.32) | ||||||||
| Male gender (%) | 261 | (33.5) | 222/667 | (33.3) | 37/106 | (34.9) | 2/5 | (40.0) | |||
| Familial IBD (N = 631) | 131 | (20.8) | 107/588 | (20.3) | 24/101 | (24.0) | 0/5 | (0) | 1.32 | 0.78 | 2.17 |
| Localization (Vienna Classification) (%) (n = 778) | |||||||||||
| L1: ileum | 196 | 164/667 | (24.6) | 32/106 | (30.2) | 0/0 | (0) | 1.24 | 0.80 | 1.94 | |
| L2: colon | 194 | 163 | (24.2) | 28 | (26.4) | 3 | (60.0) | 1.20 | 0.76 | 1.88 | |
| L3: ileocolonic | 388 | 340 | (51.0) | 46 | (43.4) | 2 | (40.0) | 0.73 | 0.49 | 1.10 | |
| L4: upper disease | 43 | 36 | (5.4) | 7 | (6.6) | 0 | (0) | 1.18 | 0.51 | 2.72 | |
| Disease behavior (Montreal classification) (%) (n = 776) | |||||||||||
| B1: non structuring, non penetrating (%) | 291 | (37.5) | 250/665 | (37.6) | 39/106 | (36.8) | 2/5 | (40.0) | 0.97 | 0.64 | 1.47 |
| B2: structuring | 215 | (27.7) | 187 | (28.1) | 27 | (25.5) | 1 | (20.0) | 0.86 | 0.54 | 1.37 |
| B3: penetrating | 270 | (34.8) | 228 | (34.3) | 40 | (37.7) | 2 | (40.0) | 1.16 | 0.77 | 1.77 |
| Extraintestinal disease (%) (n = 750) | 151 | (20.1) | 125/642 | (19.5) | 26/103 | (25.2) | 0/5 | (0) | 1.31 | 0.81 | 2.13 |
| Perianal disease (%) (n = 643) | 177 | (27.5) | 149/548 | (27.2) | 26/90 | (28.9) | 2/5 | (40.0) | 1.12 | 0.69 | 1.81 |
| Surgery (n = 774) | 411 | (53.1) | 355/664 | (53.5) | 54/105 | (51.4) | 2/5 | (40.0) | 0.90 | 0.60 | 1.35 |
Values are presented as absolute numbers (percentages).
*Carriers of the mutant allele (T/G and G/G) were compared to wild-types (T/T).