Table 3. Association between DECTIN-1 genotypes and clinical characteristics in a subset of ulcerative colitis patients from whom detailed phenotypic data were available (N = 759).
| Characteristic | Total cohort UC | (%) | T/T | (%) | T/G | (%) | G/G | (%) | Odds ratio* | 95% CI* | |
| Age at diagnosis (SD) | 36.3 (±14.4) | 33.9 (±12.9) | 35.5 (±10.4) | ||||||||
| Male gender | 401 | (52.8) | 346/655 | (52.8) | 52/100 | (52.0) | 3/4 | (75.0) | |||
| Localization (Montreal) (n = 721) | |||||||||||
| E1 (Proctitis) | 124 | (17.2) | 110/623 | (17.7) | 14/95 | (14.7) | 0/3 | (0) | 0.78 | 0.43 | 1.42 |
| E2 (Left sided) | 245 | (44.0) | 212 | (34.0) | 33 | (34.7) | 0 | (0) | 0.98 | 0.63 | 1.54 |
| E3 (Extended/pancolitis) | 352 | (48.8) | 301 | (48.3) | 48 | (50.5) | 3 | (100) | 1.16 | 0.76 | 1.79 |
| Extraintestinal disease (n = 228) | 42 | (18.4) | 33/183 | (18.0) | 8/43 | (18.6) | 1/2 | (50) | 1.14 | 0.50 | 2.59 |
| Surgery (n = 759) | 145 | (19.1) | 120/655 | (18.3) | 24/100 | (24.0) | 1/4 | (25.0) | 1.41 | 0.86 | 2.31 |
| Malignancy (n = 384) | 2 | (0.5) | 1/329 | (0.3) | 1/53 | (1.9) | 0/2 | (0) | 6.07 | 0.37 | 98.57 |
| Family diagnosis of IBD (n = 547) | 81 | (14.8) | 72/472 | (15.3) | 9/72 | (12.5) | 0/3 | (0) | 0.76 | 0.36 | 1.59 |
Values are presented as absolute numbers (percentages).
*Carriers of the mutant allele (T/G and G/G) were compared to wild-types (T/T).