Figure 3. Integration of mutation and chromosomal copy number data from TCGA reveals aberrations of EGFR to be mutually exclusive of aberrations in PDGFRA and NF1.

Summary of copy number aberrations (CNA) and mutations of EGFR, PDGFR and NF1 genes in 278 glioblastoma samples from The Cancer Genome Atlas. 163 samples showed mutation/aberration of at least one of the genes. For this summary, only validated, non-synonymous somatic mutations were considered (164/278 samples had sequencing information available). CNA was defined as focal high-amplitude amplification (>4 copies) of EGFR or PDGFR, and by at least single-copy loss of NF1.